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Current Traditional Medicine

Author(s): Mohd Masih Uzzaman Khan*, Habibullah Khalilullah, Eltayeb E.M. Eid, Faizul Azam, Masood Alam Khan, Arif Khan, Nasir Ali Siddiqui, Tarique Mahmood, Farogh Ahsan, Wasi Uzzaman Khan, Nitish Bhatia, Danish Mahmood and Md. Jamir Anwar

DOI: 10.2174/2215083807666210119110714

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A Dig Deep to Scout the Pharmacological and Clinical Facet of Garlic (Allium sativum)

Article ID: e161021190434 Pages: 19

  • * (Excluding Mailing and Handling)

Abstract

Garlic, Allium sativum L., is a culinary herb that has been employed medicinally since ancient times. Garlic has been regarded as the oldest of all cultivated plants. Various experimental as well as human studies have demonstrated that garlic is used in preventing the initiation and evolution of several ailments such as hypertension, atherosclerosis, diabetes mellitus, cancer, microbial infections, arthritis, thrombosis, and Alzheimer’s disease. It can also act as an anti-oxidant. The preclinical toxicity study gives an impression that garlic is safe, although allergic reactions may occur. Recently, there has been systematic research regarding garlic, and positive results have been attained in healing many diseases. For centuries many countries of different civilizations and continents protected their populations and healed themselves using garlic. Therefore, there is an augmented necessity of investigation on the history of garlic for the sake of strengthening the ability of physicians and pharmacists to deal with the challenges arising in the provision of specialized facilities to serve mankind. The present review provides morphological, pharmacological, and toxicological insight regarding garlic. Further studies are required to explicate the therapeutic mode of action of garlic along with its potency, effectiveness, and clinical wellbeing in the management of different ailments.

Keywords: Garlic, Allium sativum, toxicity study, immunity, anti-microbial, hypertension.

Graphical Abstract

[1]
Singh VK, Singh K. Pharmacological Effects of Garlic (Allium sativum L.). Annu Rev Biomed Sci 2008; 12: 10-3.
[2]
Tattelman E. Health effects of garlic. Am Fam Physician 2005; 72(1): 103-6.
[PMID: 16035690]
[3]
Garlic: A review of its medicinal effects and indicated active compounds. ACS Symp Series 176-209.
[http://dx.doi.org/10.1021/bk-1998-0691.ch014]
[4]
Moyers S. Garlic in health, history, and world cuisine. (1st ed) St Petersburg, Florida Suncoast Press1996;
[5]
Woodward P. Garlic and friends: the history, growth and use of edible Alliums. 1st edMelbourne, Australia Hyland House 1996.
[6]
Petrovska B, Cekovska S. Extracts from history and medical properties of garlic. Pharmacogn Rev 2010; 4: 106-10.
[http://dx.doi.org/10.4103/0973-7847.65321] [PMID: 22228949]
[7]
Rivlin R. Patient with hyperlipidemia who received garlic supplements. Lipid management. Rep from Lipid Educ Counc 1998; 3: 6-7.
[8]
Borek C. Antioxidant health effects of aged garlic extract. J Nutr 2001; 131(3s): 1010S-5S.
[http://dx.doi.org/10.1093/jn/131.3.1010S] [PMID: 11238807]
[9]
Bayan L, Koulivand PH, Gorji A. Garlic: A review of potential therapeutic effects. Avicenna J Phytomed 2014; 4(1): 1-14.
[PMID: 25050296]
[10]
Hiyasat B, Sabha D, Grötzinger K, et al. Antiplatelet activity of Allium ursinum and Allium sativum. Pharmacology 2009; 83(4): 197-204.
[http://dx.doi.org/10.1159/000196811] [PMID: 19174616]
[11]
Lallemand J, Messian CM, Briand F, et al. Delimitation of varietal groups in garlic (Alliumsativum L.) by morphologigal, physiological and biochemical. characters. Acta Hortic 1997; (433): 123-32.
[http://dx.doi.org/10.17660/ActaHortic.1997.433.10]
[12]
Zeng Y, Li Y, Yang J, et al. Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being. Evid Based Complement Alternat Med 2017; 2017
[http://dx.doi.org/10.1155/2017/9402849] [PMID: 28261311]
[13]
Ryu K, Ide N, Matsuura H, Itakura Y. N alpha-(1-deoxy-D-fructos-1-yl)-L-arginine, an antioxidant compound identified in aged garlic extract. J Nutr 2001; 131(3s): 972S-6S.
[http://dx.doi.org/10.1093/jn/131.3.972S] [PMID: 11238799]
[14]
Abdullah TH, Kandil O, Elkadi A, Carter J. Garlic revisited: therapeutic for the major diseases of our times? J Natl Med Assoc 1988; 80(4): 439-45.
[PMID: 3290502]
[15]
Mansell P, Reckless JP. Garlic. BMJ 1991; 303(6799): 379-80.
[http://dx.doi.org/10.1136/bmj.303.6799.379] [PMID: 1912802]
[16]
Jang HJ, Lee HJ, Yoon DK, Ji DS, Kim JH, Lee CH. Antioxidant and antimicrobial activities of fresh garlic and aged garlic by-products extracted with different solvents. Food Sci Biotechnol 2017; 27(1): 219-25.
[http://dx.doi.org/10.1007/s10068-017-0246-4] [PMID: 30263743]
[17]
Török B, Belágyi J, Rietz B, Jacob R. Effectiveness of garlic on the radical activity in radical generating systems. Arzneimittelforschung 1994; 44(5): 608-11.
[PMID: 8024631]
[18]
Bordia A. Effect of garlic on blood lipids in patients with coronary heart disease. Am J Clin Nutr 1981; 34(10): 2100-3.
[http://dx.doi.org/10.1093/ajcn/34.10.2100] [PMID: 7293938]
[19]
Yeh GY, Davis RB, Phillips RS. Use of complementary therapies in patients with cardiovascular disease. Am J Cardiol 2006; 98(5): 673-80.
[http://dx.doi.org/10.1016/j.amjcard.2006.03.051] [PMID: 16923460]
[20]
Borek C. Garlic reduces dementia and heart-disease risk. J Nutr 2006; 136(3)(Suppl.): 810S-2S.
[http://dx.doi.org/10.1093/jn/136.3.810S] [PMID: 16484570]
[21]
Nwokocha CR, Ozolua RI, Owu DU, Nwokocha MI, Ugwu AC. Antihypertensive properties of Allium sativum (garlic) on normotensive and two kidney one clip hypertensive rats. Niger J Physiol Sci 2011; 26(2): 213-8.
[PMID: 22547193]
[22]
Vazquez-Prieto MA, González RE, Renna NF, Galmarini CR, Miatello RM. Aqueous garlic extracts prevent oxidative stress and vascular remodeling in an experimental model of metabolic syndrome. J Agric Food Chem 2010; 58(11): 6630-5.
[http://dx.doi.org/10.1021/jf1006819] [PMID: 20450156]
[23]
Capraz M, Dilek M, Akpolat T. Garlic, hypertension and patient education. Int J Cardiol 2007; 121(1): 130-1.
[http://dx.doi.org/10.1016/j.ijcard.2006.08.060] [PMID: 17088002]
[24]
Benavides GA, Squadrito GL, Mills RW, et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA 2007; 104(46): 17977-82.
[http://dx.doi.org/10.1073/pnas.0705710104] [PMID: 17951430]
[25]
McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993; 13(4): 406-7.
[PMID: 8361870]
[26]
Silagy CA, Neil HAW. A meta-analysis of the effect of garlic on blood pressure. J Hypertens 1994; 12(4): 463-8.
[http://dx.doi.org/10.1097/00004872-199404000-00017] [PMID: 8064171]
[27]
Dubey H, Singh A, Patole AM, Tenpe CR. Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats. Integr Med Res 2017; 6(1): 60-5.
[http://dx.doi.org/10.1016/j.imr.2016.12.002] [PMID: 28462145]
[28]
Sharifi AM, Darabi R, Akbarloo N. Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J Ethnopharmacol 2003; 86(2-3): 219-24.
[http://dx.doi.org/10.1016/S0378-8741(03)00080-1] [PMID: 12738090]
[29]
Fukao H, Yoshida H, Tazawa Y, Hada T. Antithrombotic effects of odorless garlic powder both in vitro and in vivo. Biosci Biotechnol Biochem 2007; 71(1): 84-90.
[http://dx.doi.org/10.1271/bbb.60380] [PMID: 17213677]
[30]
Lau BHS, Lam F, Wang-Cheng R. Effect of an odor-modified garlic preparation on blood lipids. Nutr Res 1987; 7: 139-49.
[http://dx.doi.org/10.1016/S0271-5317(87)80026-X]
[31]
Vidyashankar S, Sambaiah K, Srinivasan K. Dietary garlic and onion reduce the incidence of atherogenic diet-induced cholesterol gallstones in experimental mice. Br J Nutr 2009; 101(11): 1621-9.
[http://dx.doi.org/10.1017/S0007114508118748] [PMID: 18983715]
[32]
Andrianova IV, Demidova OM, Medvedeva LA, Latyshev OA. [Correction of hyperlipidemia with Allicor]. Klin Med (Mosk) 2004; 82(4): 56-8.
[PMID: 15164512]
[33]
Augusti KT, Arathy SL, Asha R, et al. A comparative study on the beneficial effects of garlic (Allium sativum Linn), amla (Emblica Officinalis Gaertn)and onion (Allium cepa Linn) on the hyperlipidemia induced by butter fat and beef fat in rats. Indian J Exp Biol 2001; 39(8): 760-6.
[PMID: 12018576]
[34]
Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S. Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds. Iran J Basic Med Sci 2013; 16(10): 1031-48.
[PMID: 24379960]
[35]
Lutomski J. Components and biological properties of some Allium species. Pozn Inst Med Plants 1987; pp.1-58.
[36]
Ernst E, Weihmayr T, Matrai A. Garlic and blood lipids. Br Med J (Clin Res Ed) 1985; 291(6488): 139.
[http://dx.doi.org/10.1136/bmj.291.6488.139-b] [PMID: 3926087]
[37]
Lau BH. Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. J Nutr 2006; 136(3)(Suppl.): 765S-8S.
[http://dx.doi.org/10.1093/jn/136.3.765S] [PMID: 16484559]
[38]
Sumioka I, Hayama M, Shimokawa Y, Shiraishi S, Tokunaga A. Lipid-lowering effect of monascus garlic fermented extract (MGFE) in hyperlipidemic subjects. Hiroshima J Med Sci 2006; 55(2): 59-64.
[PMID: 16813070]
[39]
Jeyaraj S, Shivaji G, Jeyaraj SD, Vengatesan A. Effect of combined supplementation of fish oil with garlic pearls on the serum lipid profile in hypercholesterolemic subjects. Indian Heart J 2005; 57(4): 327-31.
[PMID: 16350679]
[40]
Al-Numair KS. Hypocholesteremic and antioxidant effects of garlic (Allium sativum L.) extract in rats fed high cholesterol diet. Pak J Nutr 2009; 8: 161-6.
[http://dx.doi.org/10.3923/pjn.2009.161.166]
[41]
Ebrahimi T, Behdad B, Abbasi MA, et al. High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet. Diagn Pathol 2015; 10: 74.
[http://dx.doi.org/10.1186/s13000-015-0322-0] [PMID: 26088761]
[42]
Ohaeri OC. Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Biosci Rep 2001; 21(1): 19-24.
[http://dx.doi.org/10.1023/A:1010425932561] [PMID: 11508690]
[43]
Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 2006; 13(9-10): 624-9.
[http://dx.doi.org/10.1016/j.phymed.2005.09.010] [PMID: 17085291]
[44]
Salman H, Bergman M, Bessler H, Punsky I, Djaldetti M. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. Int J Immunopharmacol 1999; 21(9): 589-97.
[http://dx.doi.org/10.1016/S0192-0561(99)00038-7] [PMID: 10501628]
[45]
Morioka N, Sze LL, Morton DL, Irie RF. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunol Immunother 1993; 37(5): 316-22.
[http://dx.doi.org/10.1007/BF01518454] [PMID: 8402735]
[46]
Josling P. Preventing the common cold with a garlic supplement: A double-blind, placebo-controlled survey. Adv Ther 2001; 18(4): 189-93.
[http://dx.doi.org/10.1007/BF02850113] [PMID: 11697022]
[47]
Liu CT, Su HM, Lii CK, Sheen LY. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Med 2009; 75(3): 205-10.
[http://dx.doi.org/10.1055/s-0028-1088396] [PMID: 19137499]
[48]
Galeone C, Pelucchi C, Levi F, et al. Onion and garlic use and human cancer. Am J Clin Nutr 2006; 84(5): 1027-32.
[http://dx.doi.org/10.1093/ajcn/84.5.1027] [PMID: 17093154]
[49]
Dorant E, van den Brandt PA, Goldbohm RA. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogenesis 1996; 17(3): 477-84.
[http://dx.doi.org/10.1093/carcin/17.3.477] [PMID: 8631133]
[50]
Hsing AW, Chokkalingam AP, Gao YT, et al. Allium vegetables and risk of prostate cancer: a population-based study. J Natl Cancer Inst 2002; 94(21): 1648-51.
[http://dx.doi.org/10.1093/jnci/94.21.1648] [PMID: 12419792]
[51]
Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JD. Vegetables, fruit, and colon cancer in the Iowa Women’s Health Study. Am J Epidemiol 1994; 139(1): 1-15.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a116921] [PMID: 8296768]
[52]
Li Z, Le W, Cui Z. A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion. Cell Death Discov 2018; 4: 108.
[http://dx.doi.org/10.1038/s41420-018-0122-x] [PMID: 30479841]
[53]
Jabar MA, Al-Mossawi A. Susceptibility of some multiple resistant bacteria to garlic extract. Afr J Biotechnol 2007; 6: 771-6.
[54]
Tepe B, Daferera D, Sökmen M, Polissiou M, Sökmen A. In vitro antimicrobial and antioxidant activities of the essential oils and various extracts of Thymus eigii M. Zohary et P.H. Davis. J Agric Food Chem 2004; 52(5): 1132-7.
[http://dx.doi.org/10.1021/jf035094l] [PMID: 14995110]
[55]
Bajpai M, Pande A, Tewari SK, Prakash D. Phenolic contents and antioxidant activity of some food and medicinal plants. Int J Food Sci Nutr 2005; 56(4): 287-91.
[http://dx.doi.org/10.1080/09637480500146606] [PMID: 16096138]
[56]
Wojdyło A, Oszmiański J, Czemerys R. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem 2007; 105: 940-9.
[http://dx.doi.org/10.1016/j.foodchem.2007.04.038]
[57]
Tsao SM, Yin MC. In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. J Med Microbiol 2001; 50(7): 646-9.
[http://dx.doi.org/10.1099/0022-1317-50-7-646] [PMID: 11444776]
[58]
Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: In vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med 1985; 51(5): 460-1.
[http://dx.doi.org/10.1055/s-2007-969553] [PMID: 17342616]
[59]
Mozaffari Nejad AS, Shabani S, Bayat M, Hosseini SE. Antibacterial effect of garlic aqueous extract on staphylococcus aureus in hamburger. Jundishapur J Microbiol 2014; 7(11) .
[http://dx.doi.org/10.5812/jjm.13134] [PMID: 25774277]
[60]
Palaksha MN, Ahmed M, Das S. Antibacterial activity of garlic extract on streptomycin-resistant Staphylococcus aureus and Escherichia coli solely and in synergism with streptomycin. J Nat Sci Biol Med 2010; 1(1): 12-5.
[http://dx.doi.org/10.4103/0976-9668.71666] [PMID: 22096329]
[61]
Raj RK. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part- II. Indian J Physiol Pharmacol 1975; 19(1)
[PMID: 1158424]
[62]
Mirelman D, Monheit D, Varon S. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic extract (Allium sativum). J Infect Dis 1987; 156(1): 243-4.
[http://dx.doi.org/10.1093/infdis/156.1.243] [PMID: 2885381]
[63]
Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother 1997; 41(10): 2286-8.
[http://dx.doi.org/10.1128/AAC.41.10.2286] [PMID: 9333064]
[64]
Ledezma E, Apitz-Castro R. [Ajoene the main active compound of garlic (Allium sativum): a new antifungal agent]. Rev Iberoam Micol 2006; 23(2): 75-80.
[http://dx.doi.org/10.1016/S1130-1406(06)70017-1] [PMID: 16854181]
[65]
Shams-Ghahfarokhi M, Shokoohamiri M-R, Amirrajab N, et al. In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia 2006; 77(4): 321-3.
[http://dx.doi.org/10.1016/j.fitote.2006.03.014] [PMID: 16690223]
[66]
Lemar KM, Aon MA, Cortassa S, O’Rourke B, Müller CT, Lloyd D. Diallyl disulphide depletes glutathione in Candida albicans: Oxidative stress-mediated cell death studied by two-photon microscopy. Yeast 2007; 24(8): 695-706.
[http://dx.doi.org/10.1002/yea.1503] [PMID: 17534841]
[67]
Sabitha P, Adhikari PM, Shenoy SM, et al. Efficacy of garlic paste in oral candidiasis. Trop Doct 2005; 35(2): 99-100.
[http://dx.doi.org/10.1258/0049475054037084] [PMID: 15970035]
[68]
Prasad G, Sharma VD, Kumar A. Efficacy of garlic (Allium sativum L.) therapy against experimental dermatophytosis in rabbits. Indian J Med Res 1982; 75: 465-7.
[PMID: 7106885]
[69]
Amonkar SV, Reeves EL. Mosquito control with active principle of garlic, Allium sativum. J Econ Entomol 1970; 63(4): 1172-5.
[http://dx.doi.org/10.1093/jee/63.4.1172] [PMID: 5488786]
[70]
Banerjee S, Hess D, Majumder P, Roy D, Das S. The Interactions of Allium sativum leaf agglutinin with a chaperonin group of unique receptor protein isolated from a bacterial endosymbiont of the mustard aphid. J Biol Chem 2004; 279(22): 23782-9.
[http://dx.doi.org/10.1074/jbc.M401405200] [PMID: 15028723]
[71]
Srimuzipo P. Effect of fresh garlic preparation on wound treatment and skin disease in dogs. International Conference on the Role of Universities in Hands-On Education Rajamangala University of Technolog 175-80.
[72]
Jalali F, Tajik H, Javadi S. The efficacy of alcoholic extract of garlic on the healing process of experimental burn wound in the rabbit. J Anim Vet Adv 2009; 8: 655-9.
[73]
Alhashim M, Lombardo J. Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. Dermatol Surg 2020; 46(5): 618-27.
[http://dx.doi.org/10.1097/DSS.0000000000002123] [PMID: 31490311]
[74]
Jarrahi M, Vafaei A. Effect of crushed garlic extract on wound healing in albino rats. Iran J Pharm Res 2010; 0: 44-4.
[75]
Farahpour MR, Hesaraki S, Faraji D, et al. Hydroethanolic Allium sativum extract accelerates excision wound healing: Evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio. Braz J Pharm Sci 2017; 53: 15086.
[http://dx.doi.org/10.1590/s2175-97902017000115079]
[76]
Morihara N, Ushijima M, Kashimoto N, et al. Aged garlic extract ameliorates physical fatigue. Biol Pharm Bull 2006; 29(5): 962-6.
[http://dx.doi.org/10.1248/bpb.29.962] [PMID: 16651727]
[77]
Nance DM, Luczy-Bachman G, Min P, et al. Effects of aged garlic extract (AGE) on the immunosuppressive effects of stress. Brain Behav Immun 2006; 20: 50-1.
[http://dx.doi.org/10.1016/j.bbi.2006.04.096]
[78]
Kasuga S, Ushijima M, Morihara N, Itakura Y, Nakata Y. [Effect of aged garlic extract (AGE) on hyperglycemia induced by immobilization stress in mice]. Nippon Yakurigaku Zasshi 1999; 114(3): 191-7.
[http://dx.doi.org/10.1254/fpj.114.191] [PMID: 10553583]
[79]
Patten CJ, Thomas PE, Guy RL, et al. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol 1993; 6(4): 511-8.
[http://dx.doi.org/10.1021/tx00034a019] [PMID: 8374050]
[80]
Ademiluyi AO, Oboh G, Owoloye TR, Agbebi OJ. Modulatory effects of dietary inclusion of garlic (Allium sativum) on gentamycin-induced hepatotoxicity and oxidative stress in rats. Asian Pac J Trop Biomed 2013; 3(6): 470-5.
[http://dx.doi.org/10.1016/S2221-1691(13)60098-2] [PMID: 23730560]
[81]
El-Kott AF. Amelioration of Nitrateinduced Hepatotoxicity. J Med Sci 2012; 12: 85-91.
[82]
Akinyemi AJ, Faboya L, Olayide I, et al. Antioxidant and Anti-Acetylcholinesterase Activities of Essential Oils from Garlic (Allium Sativum) Bulbs. Vegetos An Int J Plant Res 2018; 31: 1-6.
[83]
Sabayan B, Foroughinia F, Chohedry A. A postulated role of garlic organosulfur compounds in prevention of valproic acid hepatotoxicity. Med Hypotheses 2007; 68(3): 512-4.
[http://dx.doi.org/10.1016/j.mehy.2006.07.055] [PMID: 17046167]
[84]
Maldonado PD, Chánez-Cárdenas ME, Pedraza-Chaverrí J. Aged garlic extract, garlic powder extract, S-allylcysteine, diallyl sulfide and diallyl disulfide do not interfere with the antibiotic activity of gentamicin. Phytother Res 2005; 19(3): 252-4.
[http://dx.doi.org/10.1002/ptr.1674] [PMID: 15934032]
[85]
Şener G, Şehirli AÖ, Ipçi Y, Cetinel S, Cikler E, Gedik N. Chronic nicotine toxicity is prevented by aqueous garlic extract. Plant Foods Hum Nutr 2005; 60(2): 77-86.
[http://dx.doi.org/10.1007/s11130-005-5103-x] [PMID: 16021835]
[86]
Friedman T, Shalom A, Westreich M. Self-inflicted garlic burns: Our experience and literature review. Int J Dermatol 2006; 45(10): 1161-3.
[http://dx.doi.org/10.1111/j.1365-4632.2006.02860.x] [PMID: 17040429]
[87]
Yin J, Li H. Anaphylaxis caused by younger garlic. J Allergy Clin Immunol 2007; 119: 34-6.
[http://dx.doi.org/10.1016/j.jaci.2006.11.151]
[88]
Kao SH, Hsu CH, Su SN, Hor WT, Chang T WH, Chow LP. Identification and immunologic characterization of an allergen, alliin lyase, from garlic (Allium sativum). J Allergy Clin Immunol 2004; 113(1): 161-8.
[http://dx.doi.org/10.1016/j.jaci.2003.10.040] [PMID: 14713923]
[89]
Saw JT, Bahari MB, Ang HH, Lim YH. Potential drug-herb interaction with antiplatelet/anticoagulant drugs. Complement Ther Clin Pract 2006; 12(4): 236-41.
[http://dx.doi.org/10.1016/j.ctcp.2006.06.002] [PMID: 17030294]
[90]
Madaus G. Lehrbuch der biologischen Heilmittel (1st ed..),. Germany: Hildesheim 1979.
[91]
World Health Organization. Bulbus Allii sativi. WHO monographs on selected medicinal plants 16-32.
[92]
Monographs ESCOP. Allii sativi bulbus Garlic Monographs. 2nd ed Stuttgart European Scientific Cooperative on Phytotherapy 2003.www.escop.com
[93]
British Herbal Medicine Association & Scientific Committee British herbal pharmacopoeiaBritish Herbal Medicine Association 1976.
[94]
British Herbal Medicine Association British Herbal PharmacopoeiaBritish Herbal Medicine Association 1983.
[95]
Goldman K. Martindale: The extra pharmacopoeia.The Pharmaceutical Press 1972.
[96]
Egen-Schwind C, Eckard R, Kemper FH. Metabolism of garlic constituents in the isolated perfused rat liver. Planta Med 1992; 58(4): 301-5.
[http://dx.doi.org/10.1055/s-2006-961471] [PMID: 1438588]
[97]
Nagae S, Ushijima M, Hatono S, et al. Pharmacokinetics of the garlic compound S-allylcysteine. Planta Med 1994; 60(3): 214-7.
[http://dx.doi.org/10.1055/s-2006-959461] [PMID: 8073085]
[98]
Dalvi RR. Alterations in hepatic phase I and phase II biotransformation enzymes by garlic oil in rats. Toxicol Lett 1992; 60(3): 299-305.
[http://dx.doi.org/10.1016/0378-4274(92)90288-U] [PMID: 1595088]
[99]
Foster BC, Foster MS, Vandenhoek S, et al. An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic. J Pharm Pharm Sci 2001; 4(2): 176-84.
[PMID: 11466175]
[100]
Ho BE, Shen DD, McCune JS, et al. Effects of garlic on cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes. Sci Pharm 2010; 78(3): 473-81.
[http://dx.doi.org/10.3797/scipharm.1002-11] [PMID: 20936048]
[101]
Asdaq SMB, Inamdar MN, Asad M. Pharmacodynamic interaction of garlic with propranolol in ischemia-reperfusion induced myocardial damage. Pak J Pharm Sci 2010; 23(1): 42-7.
[PMID: 20067865]
[102]
Aneela S, De S, Kanthal L, et al. Acute oral toxicity studies of Pongamia Pinnata and Annona squamosa on albino wister rats. Int J Res Pharm Chem 2011; 1: 820-4.
[103]
Kumari M, Saifi A, Khan M, et al. Acute and subchronic oral toxicity studies of majun brahmi and itrifal muqawwi dimagh (traditional unani formulations) in rats. Pharmacognosy Res 2020; 12: 175.
[104]
Fowotade A, Fowotade A. Evaluating toxicity profile of garlic (Allium sativum) on the liver, kidney and heart using Wistar rat model. Int J Trop Dis Health 2017; 26: 1-2.
[http://dx.doi.org/10.9734/IJTDH/2017/36282]
[105]
Lawal B, Shittu OK, Oibiokpa FI, et al. Antimicrobial evaluation, acute and sub-acute toxicity studies of Allium sativum. J Acute Dis 2016; 5: 296-301.
[http://dx.doi.org/10.1016/j.joad.2016.05.002]
[106]
Njue G, Ombui N, Kanja W, et al. Evaluation of oral toxicity level of ethyl acetate extract, from garlic (allium sativum) in onorrh dawleys rats as per OECD guidelines 423. J Food Sci Technol 2015; 2: 56-064.
[107]
de Torrescasana EU. Experimental study on pharmacology of the active principles of allium sativum. Rev Esp Fisiol 1946; 2: 6-31.
[108]
Yoshida S, Hirao Y, Nakagawa S. [Mutagenicity and cytotoxicity tests of garlic]. J Toxicol Sci 1984; 9(1): 77-86.
[http://dx.doi.org/10.2131/jts.9.77] [PMID: 6471131]
[109]
Mills SY, Bone K. The Essential Guide to Herbal Safety. 1st ed Churchill Livingstone 2004.https://www.elsevier.com/books/the-essential-guide-to-herbal-safety/mills/978-0-443-07171-3
[110]
Nwanjo H, Oze G. Anti-arrythemic and anti-hyperlipidaemic potentials of aqueous garlic extract in hyper-cholesterolaemic rat. Int J Nat Appl Sci 2008; 3: 214-21.
[http://dx.doi.org/10.4314/ijonas.v3i2.36173]
[111]
Aliu Y, Nwude N. Veterinary pharmacology and toxicology experiments 2nd ed Ahmadu Bello University Press. 1982.
[112]
Mikail HG. Phytochemical screening, elemental analysis and acute toxicity of aqueous extract of Allium sativum L. bulbs in experimental rabbits. J Med Plants Res 2010; 4: 322-6.
[113]
Joseph PK, Rao KR, Sundaresh CS. Toxic effects of garlic extract and garlic oil in rats. Indian J Exp Biol 1989; 27(11): 977-9.
[PMID: 2620938]
[114]
Raghunandana R, Natarajan S. Toxicity of pterygospermin and allicin Proceedings of the Indian Academy of Sciences-Section B 4th ed.. https://link.springer.com/content/pdf/10.1007/BF03049967.pdf1949.
[115]
Cavallito CJ, Bailey JH. Allicin, the antibacterial principle of Allium sativum. I. isolation, physical properties and antibacterial action. J Am Chem Soc 1944; 66: 1950-1.
[http://dx.doi.org/10.1021/ja01239a048]
[116]
Christensen H, Luginbyhl T. Registry of toxic effects of chemical substances. Rockville, Maryland, USA US Department of Health, Education, and Welfare Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health 1974.https://www.osti.gov/biblio/6678393
[117]
Dixit VP, Joshi S. Effects of chronic administration of garlic (Allium sativum Linn) on testicular function. Indian J Exp Biol 1982; 20(7): 534-6.
[PMID: 7173985]
[118]
Hammami I, Nahdi A, Mauduit C, et al. The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding. Asian J Androl 2008; 10(4): 593-601.
[http://dx.doi.org/10.1111/j.1745-7262.2008.00358.x] [PMID: 18097508]
[119]
Hammami I, Amara S, Benahmed M, El May MV, Mauduit C. Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action. Reprod Biol Endocrinol 2009; 7: 65.
[http://dx.doi.org/10.1186/1477-7827-7-65] [PMID: 19552815]
[120]
Jubb AC, Cederquist D, Nitchals RM, et al. Effects of diets containing foods with possible antibiotic properties on the growth and development of white rats. Q Bull Michigan State Univ Agric Exp Stn 1947; 30: 136-49.
[121]
Carl M, Mcknight RS, Scott B, et al. Physiological effects of garlic and derived substances. Am J Epidemiol 1939; 29: 32-5.
[122]
Nakagawa S, Masamoto K, Sumiyoshi H, Kunihiro K, Fuwa T. [Effect of raw and extracted-aged garlic juice on growth of young rats and their organs after peroral administration (author’s transl)]. J Toxicol Sci 1980; 5(1): 91-112.
[http://dx.doi.org/10.2131/jts.5.91] [PMID: 7431442]
[123]
Banerjee SK, Maulik M, Manchanda SC, Dinda AK, Das TK, Maulik SK. Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food Chem Toxicol 2001; 39(8): 793-7.
[http://dx.doi.org/10.1016/S0278-6915(01)00018-7] [PMID: 11434986]
[124]
Shashikanth KN, Basappa SC, Murthy VS. Effect of feeding raw and boiled garlic (A. sativum L.) extracts on the growth, caecal microflora and serum proteins of albino rats. Nutr Rep Int 1986; 33: 313-9.
[125]
hHromichi Sumiyoshi, Kanezawa A, Masamoto K, et al. Chronic toxicity test of garlic extract in rats. J Toxicol Sci 1984; 9: 61-75.
[126]
Abraham SK, Kesavan PC. Genotoxicity of garlic, turmeric and asafoetida in mice. Mutat Res 1984; 136(1): 85-8.
[http://dx.doi.org/10.1016/0165-1218(84)90138-1] [PMID: 6717474]
[127]
Das T, Choudhury AR, Sharma A, Talukder G. Effects of crude garlic extract on mouse chromosomes in vivo. Food Chem Toxicol 1996; 34(1): 43-7.
[http://dx.doi.org/10.1016/0278-6915(95)00090-9] [PMID: 8603796]
[128]
Schimmer O, Häfele F, Krüger A. The mutagenic potencies of plant extracts containing quercetin in Salmonella typhimurium TA98 and TA100. Mutat Res 1988; 206(2): 201-8.
[http://dx.doi.org/10.1016/0165-1218(88)90161-9] [PMID: 3050500]
[129]
Charles GD, Linscombe VA, Tornesi B, Mattsson JL, Gollapudi BB. An in vitro screening paradigm for extracts of whole foods for detection of potential toxicants. Food Chem Toxicol 2002; 40(10): 1391-402.
[http://dx.doi.org/10.1016/S0278-6915(02)00085-6] [PMID: 12387301]
[130]
Kalantari H, Larki A, Latifi SM. The genotoxicity study of garlic and pasipy herbal drops by peripheral blood micronucleus test. Acta Physiol Hung 2007; 94(3): 261-6.
[http://dx.doi.org/10.1556/APhysiol.94.2007.3.10] [PMID: 17853777]