Background: Xylometazoline, a sympathomimetic agent, is considered safe in hypertensive patients as a relief measure for nasal congestion with intranasal application.
Case Report: In the present case, a 58-year old male patient, having ischemic heart disease, controlled hypertension on telmisartan and bisoprolol, experienced hypertensive urgency in a span of two hours of intranasal administration of the paediatric formulation of xylometazoline.
Conclusion: The interaction with bisoprolol should be kept in mind while using xylometazoline.
Keywords: Xylometazoline, sympathomimetic agent, bisoprolol, interaction, hypertensive urgency, intranasal.