Abstract

Background:In this research work, a drug sensor (salicylic acid, in this case) was designed . The senor was made by modification of paste electrode (MPE) with CuO-SWCNTs and 1- hexyl-3-methylimidazolium chloride (HMICl). The MPE/CuO-SWCNTs/HMICl showed catalytic activity for the oxidation signal of salicylic acid in phosphate buffer solution

Methods:Electrochemical methods were used as a powerful strategy for the determination of salicylic acid in pharmaceutical samples. Aiming at this goal, the carbon paste electrode was amplified with conductive materials and used as a working electrode.

Results:The MPE/CuO-SWCNTs/HMICl was used for the determination of salicylic acid in the concentration range of 1.0 nM – 230 μM using the differential pulse voltammetric (DPV) method. At pH=7.0, as optimum condition, the MPE/CuO-SWCNTs/HMICl displayed a high-quality ability for the determination of salicylic acid in urine, pharmaceutical serum, and water samples.

Conclusion: The MPE/CuO-SWCNTs/HMICl was successfully used as a new and highperformance working electrode for the determination of salicylic acid at a nanomolar level and in real samples.

Keywords: Salicylic acid, CuO-SWCNTs, electrochemical sensor, ionic liquid, electroanalytical sensor, pharmaceutical samples.