Author(s): Kong Zhang, Tianze Li, Xijie Shan, Rongfei Lu, Shaoyong Zhang and Hui Xu*
Page: [1830 - 1848] Pages: 19
* (Excluding Mailing and Handling)
Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.
Keywords: Cholesterol derivatives, biological activities, structural modification, mechanisms of action, structure-activity relationships.
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