Ethanolamine: A Potential Promoiety with Additional Effects on the Brain

Asfree       Gwanyanya; Christie    Nicole    Godsmark; Roisin       Kelly-Laubscher
Abstract

Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process, ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological actions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer’s disease. This mini-review focuses on the effects of ethanolamine on the CNS and highlights the possible implications of these effects for drug design.
Keywords: Ethanolamine, brain, CNS, phospholipids, prodrug, synaptic, neuromodulator
Graphical Abstract

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Cite As
CNS & Neurological Disorders - Drug Targets

Ethanolamine: A Potential Promoiety with Additional Effects on the Brain

Abstract

Graphical Abstract
