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Mini-Reviews in Medicinal Chemistry

Author(s): Sedighe Forouhari, Elahe Mahmoudi, Esmat Safdarian, Zahra Beygi and Seyed Mohammad Gheibihayat*

DOI: 10.2174/1389557520999201209213319

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MicroRNA: A Potential Diagnosis for Male Infertility

Page: [1226 - 1236] Pages: 11

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Abstract

Male infertility is one of the major global health problems, in particular, in more than half of the affected men. Genetic factors are important for identifying men with idiopathic infertility along with semen analysis. Valid and useful information can be obtained through non-invasive molecular research. Among these, small single-stranded non-coding RNA molecules of microRNAs (abbreviated miRNAs) are non-invasive biomarkers with a diagnostic value by regulating the post-transcriptional gene silence through repression and prevention of the translation process. The association between various types of male infertility and miRNA regulation changes has been evaluated to understand the biological function of miRNA and gene targets. Accordingly, further study of the function of miRNAs associated with reproductive disorders could lead researchers to further understand the molecular mechanisms of male infertility in order to find effective biomarkers and therapeutic strategies. Therefore, the present review article aimed at scrutinizing those researches investigating the altered miRNA expression in testicles, epididymis, and spermatozoa.

Keywords: Infertility, MicroRNA, miRNA, spermatozoa, testis.

Graphical Abstract

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