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Current Diabetes Reviews

Author(s): V. Manimaran*, Ponnurengam Malliappan Sivakumar, J. Narayanan, Shanmugam Parthasarathi and Pranav Kumar Prabhakar*

DOI: 10.2174/1573399817666201209095205

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Nanoemulsions: A Better Approach for Antidiabetic Drug Delivery

Page: [486 - 495] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology, which is very suitable for the delivery of antidiabetic drugs. In recent years, the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also provide the therapeutic agent for a longer duration. Generally, nanoemulsions are made up of either oil-in-water or water-in-oil and the size of the droplets is from fifty to thousand nanometer. Surfactants are critical substances that are added in the manufacturing of nanoemulsions. Only the surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer. Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.

Keywords: Diabetes mellitus , conventional drugs , nanoemulsion , nanomedicine , surfactants , hypoglycemic .

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