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Current Pharmaceutical Design

Author(s): Andrea Demarchi, Alberto Somaschini, Stefano Cornara and Emmanuel Androulakis*

DOI: 10.2174/1389201021666201126143217

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Peripheral Artery Disease in Diabetes Mellitus: Focus on Novel Treatment Options

Page: [5953 - 5968] Pages: 16

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Abstract

Diabetes mellitus (DM) and peripheral artery disease (PAD) are two clinical entities closely associated. They share many pathophysiological pathways such as inflammation, endothelial dysfunction, oxidative stress and pro-coagulative unbalance. Emerging data focusing on agents targeting these pathways may be promising. Moreover, due to the increased cardiovascular risk, there is a growing interest in cardiovascular and “pleiotropic” effects of novel glucose lowering drugs. This review summarizes the main clinical features of PAD in patients, the diagnostic process and current medical/interventional approaches, ranging from “classical treatment” to novel agents.

Keywords: Diabetes mellitus, peripheral artery disease, novel treatments, pro-coagulative unbalance, pleiotropic, endothelial dysfunction.

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