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Mini-Reviews in Medicinal Chemistry

Author(s): Jiajia Zhang, Ning Wu* and Dayong Shi*

DOI: 10.2174/1389557520666201113110406

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The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review

Page: [803 - 815] Pages: 13

  • * (Excluding Mailing and Handling)

Abstract

Background: The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes.

Methodology: We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer.

Results: We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases.

Conclusion: There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.

Keywords: Signaling pathway, mammalian target of rapamycin, protein tyrosine phosphatase 1b, dipeptidase 4, cancer, diabetes, pharmacology, target compounds.

Graphical Abstract

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