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Letters in Organic Chemistry

Author(s): Ling Wu, Qingpeng Zeng, Pinghua Hu, Taoqi Zong and Fengtian Wu*

DOI: 10.2174/1570178617999201110115648

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Flufenamic Acid-Promoted the Coupling of Epoxides and CO2 to Form Cyclic Carbonates

Page: [812 - 816] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

The process of hydrogen bond donor accelerating the cycloaddition of epoxides with CO2 is a green conversion. In this text, commercial drug flufenamic acid which contains O-H and N-H groups is introduced to promote the coupling. The reaction is capable of tolerating a relatively wide range of groups with the aid of catalytic system flufenamic acid/TBAB. Moreover, the reaction mechanism is proposed on the basis of reported literatures.

Keywords: Flufenamic acid, epoxide, CO2, cyclic carbonate, TBAB, phenylacetylene.

Graphical Abstract