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Current Pharmaceutical Design

Author(s): Elham Ramazani, Maryam Akaberi, Seyed Ahmad Emami and Zahra Tayarani-Najaran*

DOI: 10.2174/1381612826666201102101428

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Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms

Page: [2299 - 2316] Pages: 18

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Abstract

Background: Gamma-oryzanol (γ-oryzanol) is one of the rice bran oil (RBO) compounds, known as a principal food source throughout the world. In recent numerous experimental studies, γ-oryzanol has been revealed to have several useful pharmacological properties, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, ameliorating unpleasant menopausal symptoms, cholesterol-lowering, improving plasma lipid pattern, etc.

Methods: In this study, we reviewed the scientific literature published up until 2020, which has evaluated the biological and pharmacological activity of gamma-oryzanol. This review summarizes the published data found in PubMed, Science Direct, and Scopus.

Results and Conclusion: The present review attempts to summarize the most related articles about the pharmacological and therapeutic potential from recent studies on γ-oryzanol to gain insights into design further studies to achieve new evidence that confirm the observed effects.

Keywords: γ-oryzanol, rice bran oil, anti-oxidant, cholesterol-lowering, anti-diabetic, pharmacological.

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