Combination of Hydroxychloroquine, Melatonin and Mercaptopurine as a Possible Intervention for Prophylaxis and Treatment of Novel COVID-19 Infection

Gyan       Vardhan; Vikas       Kumar; Megha       Agrawal; Puneet       Dhamija

Abstract

Background: COVID-19 has been declared as a pandemic recently and has caused many deaths worldwide. Till date, no effective drug or vaccine is available against SARS-CoV-2. There is an urgent need to find effective alternative preventive and treatment strategies to deal with the SARS-CoV- 2 outbreak.

Objective: This communication proposes a new potential drug combination (repurposed) for prophylaxis and treatment of SARS-CoV-2.

Methods and Materials: We performed a brief review of literature on a combination of Hydroxychloroquine, Melatonin and Mercaptopurine for prophylaxis and treatment of Novel COVID-19 infection and also assessed their possible mechanism of action against SARS-CoV-2.

Observation: Proposed combination seems to be safe, and the target is unlikely to develop resistance to this combination.

Conclusion: This scientific review proposes potential candidate repurposed drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.

Keywords: Novel COVID-19, Hydroxychloroquine, Melatonin, Mercaptopurine, coronavirus, Prophylaxis.

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