Abstract

A one-pot three component synthesis of a series of new gramine derivatives was designed and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl amines at 80-110 °C for 10-24 hours in an oven under solvent- and catalyst-free conditions providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were conveniently synthesized and characterized by elemental analyses, FT IR, ¹H and ¹³C NMR spectroscopic measurements.

Keywords: Multicomponent reactions, Gramine, Indole, N-Methylindole, Pyrimidine amine, Aryl aldehyde.

Graphical Abstract