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Letters in Organic Chemistry

Author(s): Anilkumar S. Patel*, Sahaj A. Gandhi, Rajesh D. Modh, Urmila H. Patel, Yogesh T. Naliapara and Naval P. Kapuriya*

DOI: 10.2174/1570178617999201012181526

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Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water

Page: [634 - 639] Pages: 6

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Abstract

An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).

Keywords: Wittig reaction, (E)-5-styrylpyrimidines, green chemistry, water-mediated, sodium tripolyphosphate.

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