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Mini-Reviews in Medicinal Chemistry

Author(s): Madhwi Ojha, Divya Yadav, Avinash Kumar, Suman Dasgupta and Rakesh Yadav*

DOI: 10.2174/1389557520666201009162804

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1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities

Page: [586 - 601] Pages: 16

  • * (Excluding Mailing and Handling)

Abstract

1, 8- Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic compounds which has garnered the interest of researchers due to its versatile biological activities. It is known to be used as an antimicrobial, anti-psychotic, anti-depressant, anti-convulsant, anti- Alzheimer’s, anti-cancer, analgesic, anti-inflammatory, antioxidant, anti-viral, anti-hypertensive, antimalarial, pesticides, anti-platelets, and CB2 receptor agonist, etc. The present review highlights the framework of biological properties of synthesized 1, 8-naphthyridine derivatives developed by various research groups across the globe.

Keywords: 1, 8-Naphthyridine derivatives, nalidixic acid, gemifloxacin, enoxacin, voreloxin, tosufolxacin.

Graphical Abstract

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