Current Organic Chemistry

Author(s): Thaipparambil Aneeja, Sankaran Radhika, Mohan Neetha and Gopinathan Anilkumar*

DOI: 10.2174/1385272824999201001153735

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An Overview of the One-pot Synthesis of Imidazolines

Page: [2341 - 2355] Pages: 15

  • * (Excluding Mailing and Handling)

Abstract

One-pot syntheses are a simple, efficient and easy methodology, which are widely used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from imidazolines. The one-pot method is an impressive approach to synthesize organic compounds as it minimizes the reaction time, separation procedures, and ecological impact. Many significant one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran, triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis. This review describes an overview of the one-pot synthesis of imidazolines and covers literature up to 2020.

Keywords: One-pot synthesis, imidazolines, ethylenediamine, green chemistry, imidazolones, organic compounds.