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Recent Patents on Anti-Cancer Drug Discovery

Author(s): Alzahraa A.M. Fergany* and Victor V. Tatarskiy

DOI: 10.2174/1574892815666200908122402

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RNA Splicing: Basic Aspects Underlie Antitumor Targeting

Page: [293 - 305] Pages: 13

  • * (Excluding Mailing and Handling)

Abstract

Background: RNA splicing, a fundamental step in gene expression, is aimed at intron removal and ordering of exons to form the protein’s reading frame.

Objective: This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities that lead to tumor progression emerge as targets for therapeutic intervention.

Methods: We discuss the role of aberrant mRNA splicing in carcinogenesis and drug response.

Results and Conclusion: Pharmacological modulation of RNA splicing sets the stage for treatment approaches in situations where mRNA splicing is a clinically meaningful mechanism of the disease.

Keywords: Cancer, molecular drug targets, RNA splicing, therapy, protein kinase inhibitors.

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