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Central Nervous System Agents in Medicinal Chemistry

Author(s): Saniya H. Khan, Sheraz Khan*, Narmeen Hashim and Inamullah Khan

DOI: 10.2174/1871524920666200810142359

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β-1,3-glucan Attenuated Chronic Unpredictable Mild Stress-induced Cognitive Impairment in Rodents via Normalizing Corticosterone Levels

Page: [206 - 217] Pages: 12

  • * (Excluding Mailing and Handling)

Abstract

Background: Chronic stress elevates the cortisol beyond normal levels, which affects cognition including learning & memory. This injurious effect is primarily mediated via over excitation of metabotropic glucocorticoid receptors (mGR).

Methods: The present study was aimed to appraise the neuroprotective effects of naturally occurring molecule β-1,3-glucan by interfering with stress-cortisol-mGR axis. Our data of virtual screening (in silico) exhibited the promising interactions of β-glucan with the mGR. Therefore, the study was extended to evaluate its efficacy (2.5, 5 and 10 mg/kg/ i.p) in an animal model of chronic unpredictable mild stress (CUMS, 28 days) induced memory impairment.

Results: Results of the current study revealed the β-glucan provided dose dependent protection against deleterious effects of stress on learning and memory associated parameters observed in Morris water maze (MWM) task. At higher tested doses, it has also significantly antagonized the stress induced weight loss and corticosterone elevation.

Keywords: β-1, 3-glucan, chronic stress, learning & memory, corticosterone, glucocorticoid receptor, glucocorticoids.

Graphical Abstract

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