Abstract

Metal complexes that hydrolyze DNA are important, due to their potential use as therapeutic agents, tools in elucidating oligonucleotide structure, and models for naturally-occurring metalloprotein nucleases. Therefore, this review focuses on recent advances in the hydrolysis of DNA and phosphate diester model compounds by non-lanthanide metal complexes.

Keywords: Mononuclear Cobalt Complexes, DNA cleavage, Zinc Complexes, Transition Metal, Dinuclear Iron