Generic placeholder image

Letters in Organic Chemistry

Author(s): Ramesh S. Ghogare*, Kalpana Patankar-Jain and Sana Amir Hamzah Momin

DOI: 10.2174/1570178617999200721011300

DownloadDownload PDF Flyer Cite As
A Simple and Efficient Protocol for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones Catalyzed by Succinic Acid Using Water as Green Reaction Medium

Page: [83 - 87] Pages: 5

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium. This method is useful for the preparat ion of various derivatives of 3,4-disubstituted isoxazol-5(4H)-ones in excellent yields.

Keywords: Succinic acid, 3, 4-disubstituted isoxazol-5(4H)-ones, Aromatic aldehydes, Ethyl acetoacetate, hydroxylamine hydrochloride, Knoevenagel condensation.