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Current Drug Delivery

Author(s): Mansureh Alizadeh, Mandana Amiri* and Abolfazl Bezaatpour

DOI: 10.2174/1567201817666200719005919

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Indirect Determination of Amikacin by Gold Nanoparticles as Redox Probe

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Abstract

Background: Amikacin is an aminoglycoside antibiotic used for many gram-negative bacterial infections like infections in the urinary tract, infections in brain, lungs and abdomen. Electrochemical determination of amikacin is a challenge in electroanalysis because it shows no voltammetric peak at the surface of bare electrodes.

Objective: In this approach, a very simple and easy method for indirect voltammetric determination of amikacin presented in real samples. Gold nanoparticles were electrodeposited at the surface of glassy carbon electrode in constant potential.

Methods: The effect of several parameters such as time and potential of deposition, pH and scan rates on signal were studied. The cathodic peak current of Au3+ decreased with increasing amikacin concentration. Quantitative analysis of amikacin was performed using differential pulse voltammetry by following cathodic peak current of gold ions.

Results: Two dynamic linear ranges of 1.0 × 10−8–1.0 × 10-7 M and 5.0 × 10−7–1.0 × 10-3 M were obtained and limit of detection was estimated 3.0× 10−9 M.

Conclusion: The method was successfully determined amikacin in pharmaceutical preparation and human serum. The effect of several interference in determination of amikacin was also studied.

Keywords: Amikacin, gold nanoparticles, electrochemical sensor, voltammetry, antibutics, human serum.

Graphical Abstract

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