Symptoms, Transmission, Prevention and Treatment of Pandemic Corona Virus: A Review

Tinsae       Kebede; Dharmendra       Kumar; Pramod    Kumar    Sharma
Abstract

Coronaviruses belong to the largest group of viruses that elicit acute respiratory, enteric and systemic infections in an extensive range of hosts. A few coronaviruses from animals can progress into a new human coronavirus that can spread from person to person. On February 12, 2020, WHO officially termed the disease as Corona Virus Disease 2019 (COVID-19) and declared it a pandemic on March 11, 2020. COVID-19 is a newly emerging viral disease that has an effect on the lower respiratory tract and shows as pneumonia. Despite laborious efforts for worldwide lockdown and quarantine, the occurrence of COVID-19 continues to increase. Proper and well-designed strategies are needed to reduce social and economic consequences arisen due to this pandemic disease. Presently, there is no effective specific vaccine and anti-viral drug supported by great-level confirmation, but dexamethasone is approved in the UK for treatment of critically ill COVID-19 patients (patients on ventilators and patients requiring only oxygen) on June 16, 2020. Further research is required to clarify the factors that affect virus pathogenesis and lethal infections.
Keywords: COVID-19, Coronaviruses, diagnostics, vaccines, pandemic, infection.
[1] 
Kahn JS, McIntosh K. History and recent advances in coronavirus discovery. Pediatr Infect Dis J  2005; 24(11)(Suppl.): S223-7.
[http://dx.doi.org/10.1097/01.inf.0000188166.17324.60] [PMID: 16378050] 
[2] 
Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol  2015; 1282: 1-23.
[http://dx.doi.org/10.1007/978-1-4939-2438-7_1] [PMID: 25720466] 
[3] 
Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med  2003; 348(20): 1967-76.
[http://dx.doi.org/10.1056/NEJMoa030747] [PMID: 12690091] 
[4] 
Peiris JS, Lai ST, Poon LL, et al. SARS study group. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet  2003; 361(9366): 1319-25.
[http://dx.doi.org/10.1016/S0140-6736(03)13077-2] [PMID: 12711465] 
[5] 
Lau SK, Woo PC, Li KS, et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA  2005; 102(39): 14040-5.
[http://dx.doi.org/10.1073/pnas.0506735102] [PMID: 16169905] 
[6] 
Li W, Shi Z, Yu M, et al. Bats are natural reservoirs of SARS-like coronaviruses. Science  2005; 310(5748): 676-9.
[http://dx.doi.org/10.1126/science.1118391] [PMID: 16195424] 
[7] 
Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol  2019; 17(3): 181-92.
[http://dx.doi.org/10.1038/s41579-018-0118-9] [PMID: 30531947] 
[8] 
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med  2012; 367(19): 1814-20.
[http://dx.doi.org/10.1056/NEJMoa1211721] [PMID: 23075143] 
[9] 
Malik YS, Sircar S, Bhat S, et al. Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments. Vet Q  2020; 40(1): 68-76.
[http://dx.doi.org/10.1080/01652176.2020.1727993] [PMID: 32036774] 
[10] 
Sahin AR, Erdogan A. Novel Coronavirus (COVID-19) outbreak: a review of the current literature. EJMO  2020; 4(1): 1-7.
[11] 
Ksiazek TG, Erdman D, Goldsmith CS, et al. SARS working group. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med  2003; 348(20): 1953-66.
[http://dx.doi.org/10.1056/NEJMoa030781] [PMID: 12690092] 
[12] 
Alagaili AN, Briese T, Mishra N, et al. Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. MBio  2014; 5(2): e00884-14.
[http://dx.doi.org/10.1128/mBio.01002-14] [PMID: 24570370] 
[13] 
Poutanen SM, Low DE, Henry B, et al. National microbiology laboratory, Canada; Canadian severe acute respiratory syndrome study team. Identification of severe acute respiratory syndrome in Canada. N Engl J Med  2003; 348(20): 1995-2005.
[http://dx.doi.org/10.1056/NEJMoa030634] [PMID: 12671061] 
[14] 
Holmes KV. SARS coronavirus: a new challenge for prevention and therapy. J Clin Invest  2003; 111(11): 1605-9.
[http://dx.doi.org/10.1172/JCI18819] [PMID: 12782660] 
[15] 
Herrewegh AA, Mähler M, Hedrich HJ, et al. Persistence and evolution of feline coronavirus in a closed cat-breeding colony. Virology  1997; 234(2): 349-63.
[http://dx.doi.org/10.1006/viro.1997.8663] [PMID: 9268167] 
[16] 
Zhong NS, Zeng GQ. Our strategies for fighting severe acute respiratory syndrome (SARS). Am J Respir Crit Care Med  2003; 168(1): 7-9.
[http://dx.doi.org/10.1164/rccm.200305-707OE] [PMID: 12773318] 
[17] 
Heusipp G, Harms U, Siddell SG, Ziebuhr J. Identification of an ATPase activity associated with a 71-kilodalton polypeptide encoded in gene 1 of the human coronavirus 229E. J Virol  1997; 71(7): 5631-4.
[http://dx.doi.org/10.1128/JVI.71.7.5631-5634.1997] [PMID: 9188639] 
[18] 
World Health Organization. Novel Coronavirus (2019 n-CoV) situation reports 2020. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/b
[19] 
World Health Organization. Emergencies preparedness, response  Available from: http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/
[20] 
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet  2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264] 
[21] 
Majumder MS, Mandl KD. Early transmissibility assessment of a novel coronavirus in Wuhan, China. Preprints  2020; 2020: 1.
[http://dx.doi.org/10.2139/ssrn.3524675] 
[22] 
Hui DSI, Azhar E, Madani TA, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis  2020; 91: 264-6.
[http://dx.doi.org/10.1016/j.ijid.2020.01.009] [PMID: 31953166] 
[23] 
Chen IY, Moriyama M, Chang MF, Ichinohe T. Severe acute respiratory syndrome coronavirus Viroporin 3a activates the NLRP3 inflammasome. Front Microbiol  2019; 10(2): 50.
[http://dx.doi.org/10.3389/fmicb.2019.00050] [PMID: 30761102] 
[24] 
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA  2020; 323(13): 1239-42.
[http://dx.doi.org/10.1001/jama.2020.2648] [PMID: 32091533] 
[25] 
Pillaiyar T, Meenakshisundaram S, Manickam M. Recent discovery and development of inhibitors targeting coronaviruses. Drug Discov Today  2020; 25(4): 668-88.
[http://dx.doi.org/10.1016/j.drudis.2020.01.015] [PMID: 32006468] 
[26] 
World Health Organization. Novel Coronavirus (2019-nCoV) advice for the public  Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019a
[27] 
Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents  2020; 55(4)105932
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105932] [PMID: 32145363] 
[28] 
Colson P, Rolain JM, Raoult D. Chloroquine for the 2019 novel coronavirus SARS-CoV-2. Int J Antimicrob Agents  2020; 55(3)105923
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105923] [PMID: 32070753] 
[29] 
Zhu N, Zhang D, Wang W, et al. China Novel Coronavirus investigating and research team. A novel coronavirus from patients with pneumonia in China. N Engl J Med  2020; 382(8): 727-33.
[http://dx.doi.org/10.1056/NEJMoa2001017] [PMID: 31978945] 
[30] 
Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci  2020; 63(3): 457-60.
[http://dx.doi.org/10.1007/s11427-020-1637-5] [PMID: 32009228] 
[31] 
Nishiura H, Jung SM, Linton NM, et al. The extent of transmission of novel coronavirus in Wuhan, China. J Clin Med  2020; 9(2): 330.
[http://dx.doi.org/10.3390/jcm9020330] 
[32] 
Kirchdoerfer RN, Cottrell CA, Wang N, et al. Pre-fusion structure of a human coronavirus spike protein. Nature  2016; 531(7592): 118-21.
[http://dx.doi.org/10.1038/nature17200] [PMID: 26935699] 
[33] 
Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome related coronaviruse: the species and its viruses – a statement of the Coronavirus study group. bioRxiv  2020; 2020: 1.
[http://dx.doi.org/doi.org/10.1101/2020.02.07.937862] 
[34] 
Lam TTY, Shum MHH, Zhu HC, et al. Identification of 2019-nCoV related coronaviruses in Malayan pangolins in Southern China. bioRxiv  2020; 2020: 1.
[http://dx.doi.org/doi.org/10.1038/s41586-020-2169-0] 
[35] 
Zhang L, Shen FM, Chen F, Lin Z. Origin and evolution of the 2019 novel coronavirus. Clin Infect Dis  2020; 71(15): 882-3.
[http://dx.doi.org/10.1093/cid/ciaa112] 
[36] 
Yang Y, Lu Q, Liu M, et al. Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. MedRxiv preprint  2020; 2020: 1.
[37] 
Luk HKH, Li X, Fung J, Lau SKP, Woo PCY. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect Genet Evol  2019; 71: 21-30.
[http://dx.doi.org/10.1016/j.meegid.2019.03.001] [PMID: 30844511] 
[38] 
Wuhan health committee (WHC), Notice on the issuance of unexplained viral pneumonia..  Available from: http://www.wuhan.gov.cn/front/web/show
[39] 
Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv  2020; 2020: 1.
[40] 
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature  2020; 579(7798): 270-3.
[http://dx.doi.org/10.1038/s41586-020-2012-7] [PMID: 32015507] 
[41] 
Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill  2020; 25(3): 245.
[http://dx.doi.org/10.2807/1560-7917.ES.2020.25.3.2000045] [PMID: 31992387] 
[42] 
Chu DKW, Pan Y, Cheng SMS, et al. Molecular diagnosis of a novel coronavirus (2019-ncov) causing an outbreak of pneumonia. Clin Chem  2020; 66(4): 549-55.
[http://dx.doi.org/10.1093/clinchem/hvaa029] [PMID: 32031583] 
[43] 
Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet  2020; 395(10226): 809-15.
[http://dx.doi.org/10.1016/S0140-6736(20)30360-3] [PMID: 32151335] 
[44] 
Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology  2018; 23(2): 130-7.
[http://dx.doi.org/10.1111/resp.13196] [PMID: 29052924] 
[45] 
Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses  2020; 12(2): 135.
[http://dx.doi.org/10.3390/v12020135] [PMID: 31991541] 
[46] 
Holshue ML, DeBolt C, Lindquist S, et al. Washington State 2019-nCoV case investigation team. First case of 2019 Novel Coronavirus in the United States. N Engl J Med  2020; 382(10): 929-36.
[http://dx.doi.org/10.1056/NEJMoa2001191] [PMID: 32004427] 
[47] 
World Health Organization. Novel Coronavirus 2019. Available from: https://www.who.int/emergencies/diseases/novel-corona-virus-2019/technical-guidance/laboratory-guidance
[48] 
Riou J, Althaus CL. Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020. Euro Surveill  2020; 25(4)2000058
[http://dx.doi.org/10.2807/1560-7917.ES.2020.25.4.2000058] [PMID: 32019669] 
[49] 
Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med  2020; 382(10): 970-1.
[http://dx.doi.org/10.1056/NEJMc2001468] [PMID: 32003551] 
[50] 
Pang J, Wang MX, Ang IYH, et al. Potential rapid diagnostics, vaccine and therapeutics for 2019 Novel Coronavirus (2019-nCoV): a systematic review. J Clin Med  2020; 9(3): 623.
[http://dx.doi.org/10.3390/jcm9030623] [PMID: 32110875] 
[51] 
Cohen J. New coronavirus threat galvanizes scientists. Science  2020; 367(6477): 492-3.
[http://dx.doi.org/10.1126/science.367.6477.492] [PMID: 32001631] 
[52] 
Mahase E. China coronavirus: what do we know so far? BMJ  2020; 368: m308.
[http://dx.doi.org/10.1136/bmj.m308] [PMID: 31980434] 
[53] 
Lu H. Drug treatment options for the 2019-new coronavirus (2019-nCoV). Biosci Trends  2019; 14(1): 69-71.
[http://dx.doi.org/10.5582/bst.2020.01020.] 
[54] 
Cyranoski D. This scientist hopes to test coronavirus drugs on animals in locked-down Wuhan. Nature  2020; 577(7792): 607.
[http://dx.doi.org/10.1038/d41586-020-00190-6] [PMID: 31992886] 
[55] 
Cheng VCC, Wong SC, To KKW, Ho PL, Yuen KY. Preparedness and proactive infection control measures against the emerging novel coronavirus in China. J Hosp Infect  2020; 104(3): 254-5.
[http://dx.doi.org/10.1016/j.jhin.2020.01.010] [PMID: 31962139] 
[56] 
Graham RL, Donaldson EF, Baric RS. A decade after SARS: strategies for controlling emerging coronaviruses. Nat Rev Microbiol  2013; 11(12): 836-48.
[http://dx.doi.org/10.1038/nrmicro3143] [PMID: 24217413] 
[57] 
Jiang S, He Y, Liu S. SARS vaccine development. Emerg Infect Dis  2005; 11(7): 1016-20.
[http://dx.doi.org/10.3201/1107.050219] [PMID: 16022774] 
[58] 
ClinicalTrials.gov. Efficacy and safety of hydroxychloroquine for treatment of pneumonia caused by 2019. Available from: https://clinicaltrials.gov/ct2/show/NCT04261517
[59] 
ClinicalTrials.gov. Glucocorticoid therapy for novel coronavirus critically ill patients with severe acute respiratory failure (steroidssari)  Available from: https://clinicaltrials.gov/ct2/show/NCT04244591
[60] 
Seven days in medicine: 8-14. BMJ  2020; 2020: 368.
[http://dx.doi.org/doi.org/10.1136/bmj.m132] 
[61] 
Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents  2020; 2020105949
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105949] [PMID: 32205204] 
[62] 
Du L, He Y, Zhou Y, Liu S, Zheng B-J, Jiang S. The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol  2009; 7(3): 226-36.
[http://dx.doi.org/10.1038/nrmicro2090] [PMID: 19198616] 
[63] 
Sheahan TP, Sims AC, Graham RL, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med  2017; 9(396): 1-11.
[http://dx.doi.org/10.1126/scitranslmed.aal3653] [PMID: 28659436] 
[64] 
Centers for Disease Control and Prevention (CDC). Outbreak of severe acute respiratory syndrome--worldwide. MMWR Morb Mortal Wkly Rep  2003; 52(12): 241-6.
[PMID: 12680518] 
[65] 
Kumar D, Malviya R, Sharma PK. Corona virus: a review of COVID-19. EJMO  2020; 4(1): 8-25.
[66] 
Thorlund K, Dron L, et al. A real time dashboard of clinical trials for COVID-19. Lancet Digit Health  2020; 2(6): 286-7.
[http://dx.doi.org/10.1016/S2589-7500(20)30086-8] 
[67] 
Xu J, Shi PY, Li H, et al. Broad spectrum antviral agent niclosamide and its therapeutc potental. ACS Infect Dis  2020; 6(5): 909-15.
[http://dx.doi.org/10.1021/acsinfecdis.0c00052] 
[68] 
Deng L, Li C, Zeng Q, et al. Arbidol combined with LPV/r versus LPV/r alone against Corona Virus disease 2019: a retrospective cohort study. J Infect  2020; 81(1): e1-5.
[http://dx.doi.org/10.1016/j.jinf.2020.03.002] [PMID: 32171872] 
[69] 
Liu F, Xu A, Zhang Y, et al. Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression. Int J Infect Dis  2020; 95: 183-91.
[http://dx.doi.org/10.1016/j.ijid.2020.03.013] [PMID: 32173576] 
[70] 
World Health Organization. Director-General opening remarks at the media briefing on COVID-19  Available from: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020
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