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Mini-Reviews in Medicinal Chemistry

Author(s): Denise Rampini, Diego Campos Prieto, Ana Luisa Colzi, Renan Vinícius de Araújo and Jeanine Giarolla*

DOI: 10.2174/1389557520666200711174007

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Future and Perspectives of the Zika Virus: Drug Repurposing as a Powerful Tool for Treatment Insights

Page: [1917 - 1928] Pages: 12

  • * (Excluding Mailing and Handling)

Abstract

The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramin, which present a greater quantity of experimental data to draw on for our discussion. The current treatment is palliative; therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV.

Keywords: Zika virus, drug repositioning, treatment, medicinal chemistry, infection disease, drug design.

Graphical Abstract

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