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Endocrine, Metabolic & Immune Disorders - Drug Targets

Author(s): Majid Firouzi, Hamidreza Sherkatolabbasieh* and Shiva Shafizadeh

DOI: 10.2174/1871530320666200704144912

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Genetic Anomalies of Growth Hormone Deficiency in Pediatrics

Page: [288 - 297] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Several different proteins regulate, directly or indirectly, the production of growth hormones from the pituitary gland, thereby complex genetics is involved. Defects in these genes are related to the deficiency of growth hormones solely, or deficiency of other hormones, secreted from the pituitary gland including growth hormones. These studies can aid clinicians to trace the pattern of the disease between the families, start early treatment and predict possible future consequences. This paper highlights some of the most common and novel genetic anomalies concerning growth hormones, which are responsible for various genetic defects in isolated growth and combined pituitary hormone deficiency disease.

Keywords: Hormone deficiency, growth hormone, genetic defects, pediatrics, pituitary disease, genetic anomalies.

Graphical Abstract

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