Abstract
The sequence of biochemical and cellular responses restoring the integrity of the subcutaneous tissue
of the skin is termed as wound healing. Inflammatory cytokine suppression and inflammatory transduction cascades
are the major targets for wound healing. Formulations for wound healing should promote neovascularization
and angiogenic pathways by increasing the expression of vascular endothelial growth factor, fibroblast
growth factor, and platelet-derived growth factor. Medication used for wound healing promotes antiinflammatory
associated with anti-bacterial action. In order to boost the effectiveness of current medical treatments,
the cutting-edge nanotechnology offers many novel therapies. This review summarized and discussed
wound healing, types of wounds, natural materials used for wound healing, metallic nanoparticles and current
nano drug delivery systems used for wound healing with special emphasis on the angiogenesis role in the healing
of wounds.
Keywords:
Wound, healing, angiogenesis, nano-drug, treatment, nanotechnology.
[4]
Sabale P, Bhimani B, Prajapati C, Sabale V. An overview of medicinal plants as wound healers. J Appl Pharm Sci 2012; 2(11): 143-50.
[5]
Raina R, Prawez S, Verma PK, Pankaj NK. Medicinal plants and their role in wound healing. Vet Scan 2008; 3: 1-7.
[8]
Gadien LA, Karim AK, Suliman E, Ahmaed DT, Ghada M. Formulation, characterization and stability study of Azadirachta indica (neem) fruits extract. World J Pharm Pharm Sci 2018; 8: 209-21.
[10]
Gupta VK, Kumar A. Assessment of burn wound healing property of ocimum sanctum by grading of epithelial regeneration in rabbits. Int J Med Sci Clin Invent 2018; 5: 3865-7.
[11]
Alam G, Singh MP, Singh A. Wound healing potential of some medicinal plants. Int J Pharm Sci Rev Res 2011; 9: 136-45.
[13]
Arunachalam KD, Subhashini S, Annamalai SK. Wound healing and antigenotoxic activities of Aegle marmelos with relation to its antioxidant properties. J Pharm Res 2012; 5: 1492-502.
[15]
Shirwaikar A, Ghosh S, Padma GM. Effect of Gmelina arborea Roxb. leaves on wound healing in rats. J Nat Rem 2003; 3: 45-8.