Abstract

Nitric oxide (NO) possesses many physiological effects and S-nitrosothiols have been identified in a variety of tissues exhibiting many NO-like activities. This review focuses on the latest discoveries pertaining to the biological functions of S-nitrosothiols and the recent research progress in the chemical properties and biomedical applications of RSNOs.

Keywords: S nitrosothiols, nitric oxide NO, RSNOs, superoxide catalzed RSNO, blood flow regulation, apotosis, platelet neutrophil interaactions, perinatal circulatory transition, S Nitroso 1 thiolsugars, TGSNO, S nitrosopeptides, Drug SNO conjugates, adrenergic receptor, Cu Zn superoxide dismutase, cardiac calcium release channel, cyclic nucleotide gated channel, interleukin converting enzyme, inducible nitric oxide synthase, xanthine oxidase, s Nitrosohemoglobin, disulfide, s Nitrosothiol, thiyl radical, glucopyranose