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Endocrine, Metabolic & Immune Disorders - Drug Targets

Author(s): Senthilkumar Rajendran*, Silvia Barbon and Salvatore Pucciarelli

DOI: 10.2174/1871530320666200624192517

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Spotlight on Circadian Genes and Colorectal Cancer Crosstalk

Page: [4 - 11] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Mammalian physiology is regulated by circadian clock through oscillating feedback loops controlling cellular processes and behaviors. Recent findings have led to an interesting connection between circadian disruption and colorectal cancer progression and incidence through controlling the hallmarks of cancer, namely cell cycle, cell metabolism and cell death. Deeper understanding of the circadian mechanisms that define the colorectal cancer pathophysiology is the need of the hour to define a chronotherapy for improving colorectal cancer patient survival. This review identifies the key areas in which circadian genes interact with cellular pathways to modify the outcome with respect to colorectal cancer incidence and progression.

Keywords: Circadian pathway, colorectal cancer, chronotherapy, cell death, cell cycle, cancer cell metabolism.

Graphical Abstract

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