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Coronaviruses

Author(s): Sibi Raj, Vaishali Chandel, Brijesh Rathi and Dhruv Kumar*

DOI: 10.2174/2666796701999200617155013

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Understanding the Molecular Mechanism(s) of SARS-CoV2 Infection and Propagation in Human to Discover Potential Preventive and Therapeutic Approach

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Abstract

Exported across the world might create a serious controversy. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection into the host undergoes a huge number of complex replicative machineries which remains unclear. Understanding the mechanism (s) of replication and mode of infection of SARS-CoV2 to human cells will help us in the development of novel vaccines or drugs for the eradication and prevention of the disease. This review compiles the knowledge of SARS-CoV2 replicative machinery, mode of infection to the human cells and the development of drugs and vaccines which are currently under clinical trials.

Keywords: Coronavirus, COVID-19, SARS, ACE-2, spike protein, vaccines, infection.

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