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Current Organic Chemistry

Author(s): Rukhsana Tabassum*, Muhammad Ashfaq* and Hiroyuki Oku

DOI: 10.2174/1385272824999200616122557

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Recent Advances in Transition Metal Free Synthetic Protocols for Quinoline Derivatives

Page: [1815 - 1852] Pages: 38

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Abstract

The quinoline moiety is a privileged scaffold among heterocyclic compounds that is an important construction motif in the fields of pharmaceutical chemistry. Quinoline molecule possesses a variety of therapeutic activities like antiviral, antimalarial, antibacterial, antitumor, anticancer, antioxidant antihypertensive, antifungal, anthelmintic, cardiotonic, anticonvulsant and anti-inflammatory. This review provides an insight into recent development in transition metal free novel and modified conventional synthetic routes to yield a wide variety of substituted quinolines.

Keywords: Quinoline, quinoline derivatives, transition metal free, heterocyclic compounds, synthetic protocols, therapeutic activities.

Graphical Abstract

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