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Current Pharmaceutical Design

Author(s): Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*

DOI: 10.2174/1381612826666200614175236

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Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

Page: [4569 - 4579] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Background: Skin diseases affect all the age groups of people and have an impact on patients’ physical, mental, and emotional status. Conventional topical preparation is limited with its efficacy due to low permeation, frequent application, and poor adherence to the therapy for prolong time.

Objective: The objective of this review article is to address the emerging trends of nanotechnology derived lipidic carrier systems for an effective treatment for skin disorders.

Methodology: Various research and review articles from reputed international journals were referred and compiled.

Results and Discussion: Topical drug delivery systems were found to be more effective than oral and parenteral drug delivery systems for treating skin diseases due to targeted localized applications with reduced side effects. Lipid-based nanoparticles have been found to have the potential in treating skin diseases due to the biocompatibility and the versatility of the lipids. Nanostructured lipid carriers (NLCs) have gained much attention in treating skin diseases due to improved stability of the drugs, enhanced skin permeation, retention, and better therapeutic efficacy. The review summarizes the NLCs characteristics and their application for topical delivery of various therapeutics in skin disorders. NLCs have shown great potential in effective drug delivery for the treatment of psoriasis, dermatitis, bacterial infections, and skin cancer. Its cosmetic application has opened a new area for skincare. Furthermore, safety and clinical status revealed its future commercial acceptability.

Conclusion: NLCs have been found as effective lipid nanocarriers for the delivery of topical therapeutics.

Keywords: Nanocarriers, nanostructured lipid carriers, psoriasis, skin diseases, targeted drug delivery, topical drug delivery.

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