Generic placeholder image

Current Bioactive Compounds

Author(s): Priyanka Kriplani* and Kumar Guarve

DOI: 10.2174/1573407216999200612103042

DownloadDownload PDF Flyer Cite As
Synergistic Effect of Curcumin: A Review

Page: [289 - 298] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Background: Curcumin, principal constituent extracted from dried rhizomes of Curcuma longa L., is a hydrophobic polyphenol meant to cure chronic malignancies like rheumatoid arthritis, Alzheimer’s, Inflammatory bowel disease and many common ailments related to colon, lung, stomach and skin. The objective of this review is to study the synergistic effect of curcumin.

Methods: Current prose emphasizes the synergistic effect of curcumin as a part of cancer treatment and other ailments have been identified and reviewed with particular emphasis on their scientific impact and novelty.

Results: A number of synergistic combinations have emerged with the growth of biological data sets that can prove to be useful for the pharmaceutical industry.

Conclusion: This present review will be help the researchers and industries in drug development as a new paradigm of drug discovery.

Keywords: Curcumin, Curcuma longa L., combination therapy, synergism, metastasis, cardioprotective.

Graphical Abstract

[1]
Keith, C.T.; Borisy, A.A.; Stockwell, B.R. Multicomponent therapeutics for networked systems. Nat. Rev. Drug Discov., 2005, 4(1), 71-78.
[http://dx.doi.org/10.1038/nrd1609] [PMID: 15688074]
[2]
Foucquier, J.; Guedj, M. Analysis of drug combinations: Current methodological landscape. Pharmacol. Res. Perspect., 2015, 3(3), e00149.
[http://dx.doi.org/10.1002/prp2.149] [PMID: 26171228]
[3]
Podolsky, S.H.; Greene, J.A. Combination drugs-Hype, harm, and hope. N. Engl. J. Med., 2011, 365(6), 488-491.
[http://dx.doi.org/10.1056/NEJMp1106161] [PMID: 21830965]
[4]
Mok, T.S.K.; Kim, S.W.; Wu, Y.L.; Nakagawa, K.; Yang, J.J.; Ahn, M.J.; Wang, J.; Yang, J.C.; Lu, Y.; Atagi, S.; Ponce, S.; Shi, X.; Rukazenkov, Y.; Haddad, V.; Thress, K.S.; Soria, J.C. Gefitinib plus chemotherapy versus chemotherapy in epidermal growth factor receptor mutation–positive non–small-cell lung cancer resistant to first-line gefitinib (impress): Overall survival and biomarker analyses. J. Clin. Oncol., 2017, 35(36), 4027-4034.
[http://dx.doi.org/10.1200/JCO.2017.73.9250] [PMID: 28968167]
[5]
Yang, J.C-H.; Mok, T.; Han, B.; Orlando, M.; Puri, T.; Park, K. A review of regimens combining pemetrexed with an epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of advanced nonsquamous Non-small-cell lung cancer. Clin. Lung Cancer, 2018, 19(1), 27-34.
[http://dx.doi.org/10.1016/j.cllc.2017.06.013] [PMID: 28743421]
[6]
García-Fuente, A.; Vázquez, F.; Viéitez, J.M.; García Alonso, F.J.; Martín, J.I.; Ferrer, J. CISNE: An accurate description of dose-effect and synergism in combination therapies. Sci. Rep., 2018, 8(1), 4964.
[http://dx.doi.org/10.1038/s41598-018-23321-6] [PMID: 29563526]
[7]
Mahmood, K.; Zia, K.M.; Zuber, M.; Salman, M.; Anjum, M.N. Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review. Int. J. Biol. Macromol., 2015, 81, 877-890.
[http://dx.doi.org/10.1016/j.ijbiomac.2015.09.026] [PMID: 26391597]
[8]
Katsuyama, Y.; Kita, T.; Horinouchi, S.; Horinouchi, S. Identification and characterization of multiple curcumin synthases from the herb Curcuma longa. FEBS Lett., 2009, 583(17), 2799-2803.
[http://dx.doi.org/10.1016/j.febslet.2009.07.029] [PMID: 19622354]
[9]
Wilken, R.; Veena, M.S.; Wang, M.B.; Srivatsan, E.S. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer, 2011, 10, 12.
[http://dx.doi.org/10.1186/1476-4598-10-12] [PMID: 21299897]
[10]
Prasad, S.; Gupta, S.C.; Tyagi, A.K.; Aggarwal, B.B. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnol. Adv., 2014, 32(6), 1053-1064.
[http://dx.doi.org/10.1016/j.biotechadv.2014.04.004] [PMID: 24793420]
[11]
Arablou, T.; Kolahdouz-Mohammadi, R. Curcumin and endometriosis: Review on potential roles and molecular mechanisms. Biomed. Pharmacother., 2018, 97, 91-97.
[http://dx.doi.org/10.1016/j.biopha.2017.10.119] [PMID: 29080464]
[12]
Mirzaei, H.; Shakeri, A.; Rashidi, B.; Jalili, A.; Banikazemi, Z.; Sahebkar, A. Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed. Pharmacother., 2017, 85, 102-112.
[http://dx.doi.org/10.1016/j.biopha.2016.11.098] [PMID: 27930973]
[13]
Lev-Ari, S.; Strier, L.; Kazanov, D.; Madar-Shapiro, L.; Dvory-Sobol, H.; Pinchuk, I.; Marian, B.; Lichtenberg, D.; Arber, N. Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. Clin. Cancer Res., 2005, 11(18), 6738-6744.
[http://dx.doi.org/10.1158/1078-0432.CCR-05-0171] [PMID: 16166455]
[14]
Yu, Y.; Kanwar, S.S.; Patel, B.B.; Nautiyal, J.; Sarkar, F.H.; Majumdar, A.P. Elimination of colon cancer stem-like cells by the combination of curcumin and FOLFOX. Transl. Oncol., 2009, 2(4), 321-328.
[http://dx.doi.org/10.1593/tlo.09193] [PMID: 19956394]
[15]
Patel, B.B.; Gupta, D.; Elliott, A.A.; Sengupta, V.; Yu, Y.; Majumdar, A.P. Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. Anticancer Res., 2010, 30(2), 319-325.
[PMID: 20332435]
[16]
Sankpal, U.T.; Nagaraju, G.P.; Gottipolu, S.R.; Hurtado, M.; Jordan, C.G.; Simecka, J.W.; Shoji, M.; El-Rayes, B.; Basha, R. Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species. Oncotarget, 2016, 7(3), 3186-3200.
[http://dx.doi.org/10.18632/oncotarget.6553] [PMID: 26672603]
[17]
Shpitz, B.; Giladi, N.; Sagiv, E.; Lev-Ari, S.; Liberman, E.; Kazanov, D.; Arber, N. Celecoxib and curcumin additively inhibit the growth of colorectal cancer in a rat model. Digestion, 2006, 74(3-4), 140-144.
[http://dx.doi.org/10.1159/000098655] [PMID: 17228149]
[18]
Irving, G.R.; Iwuji, C.O.; Morgan, B.; Berry, D.P.; Steward, W.P.; Thomas, A.; Brown, K.; Howells, L.M. Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial. Trials, 2015, 16, 110.
[http://dx.doi.org/10.1186/s13063-015-0641-1] [PMID: 25872567]
[19]
Santana-Bejarano, U.F.; Bobadilla-Morales, L.; Mendoza-Maldonado, L.; Torres-Anguiano, E.; Brukman-Jiménez, S.A.; Barba-Barba, C.C.; Corona-Rivera, J.R.; Corona-Rivera, A. In vitro effect of curcumin in combination with chemotherapy drugs in Pharmacute lymphoblastic leukemia cells. Oncol. Lett., 2019, 17(6), 5224-5240.
[http://dx.doi.org/10.3892/ol.2019.10204] [PMID: 31186739]
[20]
Kunnumakkara, A.B.; Diagaradjane, P.; Anand, P.; Harikumar, K.B.; Deorukhkar, A.; Gelovani, J.; Guha, S.; Krishnan, S.; Aggarwal, B.B. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int. J. Cancer, 2009, 125(9), 2187-2197.
[http://dx.doi.org/10.1002/ijc.24593] [PMID: 19623659]
[21]
Zhang, H.; Yu, T.; Wen, L.; Wang, H.; Fei, D.; Jin, C. Curcumin enhances the effectiveness of cisplatin by suppressing CD133+ cancer stem cells in laryngeal carcinoma treatment. Exp. Ther. Med., 2013, 6(5), 1317-1321.
[http://dx.doi.org/10.3892/etm.2013.1297] [PMID: 24223665]
[22]
Sahu, P.B.; Hazarika, H.; Bhardwaj, R.; Luing, P.; Baishya, R.; Dash1, KS; Das, KM Curcumin-Docetaxel co loaded nanosuspension for enhanced anticancer therapy. 58th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems. Pharm. Anal. Acta, 2016, 7, 1.
[23]
Altenburg, J.D.; Bieberich, A.A.; Terry, C.; Harvey, K.A.; Vanhorn, J.F.; Xu, Z.; Jo Davisson, V.; Siddiqui, R.A. A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: Unique signaling not explained by the effects of either compound alone. BMC Cancer, 2011, 11, 149.
[http://dx.doi.org/10.1186/1471-2407-11-149] [PMID: 21510869]
[24]
Wang, K.; Zhang, C.; Bao, J.; Jia, X.; Liang, Y.; Wang, X.; Chen, M.; Su, H.; Li, P.; Wan, J.B.; He, C. Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death. Sci. Rep., 2016, 6, 26064.
[http://dx.doi.org/10.1038/srep26064] [PMID: 27263652]
[25]
Siddiqui, A.R.; Harvey, K.; Xu, Z. Synergistic anti-cancer effects of docosahexaenoic acid and curcumin on breast cancer initiation and progression. 4th World Congress on Cancer Science & Therapy, Available at: https://grantome.com/grant/NIH/R03-CA137765-02
[26]
Misra, K; Singh, N; Singh, A; Srivastava, V; Shrivash, MK Comparative in silico/in vitro study of synergistic effect of curcuminoids as inhibitors of breast/ liver cancer cells. Adv Breast Cancer Ther, 2017, ABCT-102.
[27]
Parasramka, M.A.; Gupta, S.V. Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells. J. Oncol., 2012, 2012, 709739.
[http://dx.doi.org/10.1155/2012/709739] [PMID: 22685460]
[28]
Banerjee, S.; Singh, S.K.; Chowdhury, I.; Lillard, J.W., Jr; Singh, R. Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer. Front. Biosci. (Elite Ed.), 2017, 9, 235-245.
[http://dx.doi.org/10.2741/e798] [PMID: 28199187]
[29]
Eom, D.W.; Lee, J.H.; Kim, Y.J.; Hwang, G.S.; Kim, S.N.; Kwak, J.H.; Cheon, G.J.; Kim, K.H.; Jang, H.J.; Ham, J.; Kang, K.S.; Yamabe, N. Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. BMB Rep., 2015, 48(8), 461-466.
[http://dx.doi.org/10.5483/BMBRep.2015.48.8.216] [PMID: 25441423]
[30]
Schmidt, K.T.; Figg, W.D. The potential role of curcumin in prostate cancer: The importance of optimizing pharmacokinetics in clinical studies. Transl. Cancer Res., 2016, 5(Suppl. 6), S1107-S1110.
[http://dx.doi.org/10.21037/tcr.2016.11.04] [PMID: 30613476]
[31]
Mahammedi, H.; Planchat, E.; Pouget, M.; Durando, X.; Curé, H.; Guy, L.; Van-Praagh, I.; Savareux, L.; Atger, M.; Bayet-Robert, M.; Gadea, E.; Abrial, C.; Thivat, E.; Chollet, P.; Eymard, J.C. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: A pilot phase II study. Oncology, 2016, 90(2), 69-78.
[http://dx.doi.org/10.1159/000441148] [PMID: 26771576]
[32]
He, B.; Wei, W.; Liu, J.; Xu, Y.; Zhao, G. Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells. Oncol. Lett., 2017, 14(3), 3387-3394.
[http://dx.doi.org/10.3892/ol.2017.6627] [PMID: 28927092]
[33]
Eke-Okoro, U.J.; Raffa, R.B.; Pergolizzi, J.V., Jr; Breve, F.; Taylor, R., Jr NEMA Research Group. Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia. J. Clin. Pharm. Ther., 2018, 43(4), 460-466.
[http://dx.doi.org/10.1111/jcpt.12703] [PMID: 29722036]
[34]
Lang, A. Curcumin + Aminosalicylic acid (5ASA) versus 5ASA alone in the treatment of mild to moderate ulcerative colitis (5ASA). Sheba Medical Center Clinical trail.gov identifier: NCT01320436, 2014-2016. Available at: https://www.clinicaltrials.gov/ct2/show/NCT01320436
[35]
Toden, S.; Theiss, A.L.; Wang, X.; Goel, A. Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis. Sci. Rep., 2017, 7(1), 814.
[http://dx.doi.org/10.1038/s41598-017-00812-6] [PMID: 28400554]
[36]
Amira, Zaky; Mariam, Mahmoud; Ahmad R., Bassiouny Valproic acid potentiates curcumin-mediated neuroprotection in lipopolysaccharide induced rats. Front. Cell. Neurosci., 2014, 8, 1-12.
[37]
Richart, MS; Li, LY; Mizushina, Y; Chang, YY; Chung, YT; Chen, HG; Tzen, CTJ; Shia, SK; Hsu, LW Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection. J. Food Drug Anal., 2018, 26, 1015-1023.
[38]
Umar, S.; Shah, M A A.; Munir, M.T.; Yaqoob, M.; Fiaz, M.; Anjum, S.; Kaboudi, K.; Bouzouaia, M.; Younus, M.; Nisa, Q.; Iqbal, M.; Umar, W. Thymoquinone and curcumin significantly enhanced immune responsiveness and suppress pathogenicity of influenza viruses in turkeys. Poult. Sci., 2016, 95, 1513-1520.
[http://dx.doi.org/10.3382/ps/pew069] [PMID: 26944958]
[39]
Sasidharan, N.K.; Sreekala, S.R.; Jacob, J.; Nambisan, B. In vitro synergistic effect of curcumin in combination with third generation cephalosporins against bacteria associated with infectious diarrhea. BioMed Res. Int., 2014, 2014, 561456.
[http://dx.doi.org/10.1155/2014/561456] [PMID: 24949457]
[40]
Dhinakaran, M.; Sundarasen, S.; Arunraj, A. Detailed study on the synergistic effect of neem extract loaded with curcumin in wound healing using textile substrate. Int. Res. J. Pharm., 2017, 8(7), 104-109.
[http://dx.doi.org/10.7897/2230-8407.087126]
[41]
Mun, S.H.; Joung, D.K.; Kim, Y.S.; Kang, O.H.; Kim, S.B.; Seo, Y.S.; Kim, Y.C.; Lee, D.S.; Shin, D.W.; Kweon, K.T.; Kwon, D.Y. Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine, 2013, 20(8-9), 714-718.
[http://dx.doi.org/10.1016/j.phymed.2013.02.006] [PMID: 23537748]
[42]
Ranjbar, R.; Mohammadi, A. Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection. Biomed. Res., 2018, 29(8), 1702-1707.
[43]
Zhao, F.; Dong, H.H.; Wang, Y.H.; Wang, T.Y.; Yan, Z.H.; Yan, F.; Zhang, D.Z.; Cao, Y.Y.; Jin, Y.S. Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant Candida spp. MedChemComm, 2017, 8(5), 1093-1102.
[http://dx.doi.org/10.1039/C6MD00649C] [PMID: 30108820]
[44]
Kriplani, P.; Guarve, K.; Baghel, S.U. Novel herbal topical patch containing curcumin and Arnica montana for the treatment of osteoarthritis. Curr. Rheumatol. Rev., 2020, 16(1), 43-60.
[45]
Reddy, R.K.; Faruqui, A.A. Efficacy and tolerability of fixed dose combination of curcumin and piperine in Indian osteoarthritic patients. Int. J. Orthop. Sci., 2016, 2(4), 445-449.
[http://dx.doi.org/10.22271/ortho.2016.v2.i4g.67]
[46]
Haroyan, A.; Mukuchyan, V.; Mkrtchyan, N.; Minasyan, N.; Gasparyan, S.; Sargsyan, A.; Narimanyan, M.; Hovhannisyan, A. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complement. Altern. Med., 2018, 18(1), 7.
[http://dx.doi.org/10.1186/s12906-017-2062-z] [PMID: 29316908]
[47]
Kizhakkedath, R. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol. Med. Rep., 2013, 8(5), 1542-1548.
[http://dx.doi.org/10.3892/mmr.2013.1661] [PMID: 24002213]
[48]
Johnson, J. Curcumin and Boswellia for Knee Osteoarthritis. Natural Medicine Journal, 2018, 10, 1-2.
[49]
Lev-Ari, S.; Strier, L.; Kazanov, D.; Elkayam, O.; Lichtenberg, D.; Caspi, D.; Arber, N. Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford), 2006, 45(2), 171-177.
[http://dx.doi.org/10.1093/rheumatology/kei132] [PMID: 16249246]
[50]
Bukhari, S.N.A.; Hussain, F.; Thu, H.E.; Hussain, Z. Synergistic effects of combined therapy of curcumin and Fructus ligustri lucidi for treatment of osteoporosis: Cellular and molecular evidence of enhanced bone formation. J. Integr. Med., 2019, 17(1), 38-45.
[http://dx.doi.org/10.1016/j.joim.2018.08.003] [PMID: 30139656]
[51]
Sehgal, A.; Kumar, M.; Jain, M.; Dhawan, D.K. Synergistic effects of piperine and curcumin in modulating benzo(a)pyrene induced redox imbalance in mice lungs. Toxicol. Mech. Methods, 2012, 22(1), 74-80.
[http://dx.doi.org/10.3109/15376516.2011.603392] [PMID: 21859361]
[52]
Murad, H.A.; Suliaman, M.I.; Abdallah, H.; Abdulsattar, M. Does curcumin or pindolol potentiate fluoxetine’s antidepressant effect by a pharmacokinetic or pharmacodynamic interaction? Indian J. Pharm. Sci., 2014, 76(3), 203-210.
[PMID: 25035531]
[53]
Sanmukhani, J.; Satodia, V.; Trivedi, J.; Patel, T.; Tiwari, D.; Panchal, B.; Goel, A.; Tripathi, C.B. Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial. Phytother. Res., 2014, 28(4), 579-585.
[http://dx.doi.org/10.1002/ptr.5025] [PMID: 23832433]
[54]
Arora, V.; Kuhad, A.; Tiwari, V.; Chopra, K. Curcumin ameliorates reserpine-induced pain-depression dyad: Behavioural, biochemical, neurochemical and molecular evidences. Psychoneuroendocrinology, 2011, 36(10), 1570-1581.
[http://dx.doi.org/10.1016/j.psyneuen.2011.04.012] [PMID: 21612876]
[55]
Kang, C.; Kim, E. Synergistic effect of curcumin and insulin on muscle cell glucose metabolism. Food Chem. Toxicol., 2010, 48(8-9), 2366-2373.
[http://dx.doi.org/10.1016/j.fct.2010.05.073] [PMID: 20561944]
[56]
Antony, B.; Merina, B.; Iyer, V.S.; Judy, N.; Lennertz, K.; Joyal, S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Indian J. Pharm. Sci., 2008, 70(4), 445-449.
[http://dx.doi.org/10.4103/0250-474X.44591] [PMID: 20046768]
[57]
Ahmed, T.; Gilani, A.H. Therapeutic potential of turmeric in Alzheimer’s disease: Curcumin or curcuminoids? Phytother. Res., 2014, 28(4), 517-525.
[http://dx.doi.org/10.1002/ptr.5030] [PMID: 23873854]
[58]
Alm-Eldeen, AA; Mona, HM; Shati, AA; El-Mekkawy, H Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats, 2013, 31, 1269-1280.
[59]
Paulucci, P.V.; Couto, O.R.; Teixeira, C.C.C.; Freitas, P.A.L. Optimization of the extraction of curcumin from Curcuma longa rhizomes. Braz J. Pharmacognosy, 2013, 23(1), 94-100.
[http://dx.doi.org/10.1590/S0102-695X2012005000117]
[60]
Selvkumar, B.; Venkataraman, R. Microwave assisted synthesis of novel aryl and heteroaryl hydrazinocurcumins. Pharma Chem., 2011, 3(6), 84-88.
[61]
Kamble, K.J.; Ingale, V.M.; Kaledhonkar, D.P. Comparative study of curcumin extraction from turmeric varieties grown in Maharashtra. Afr. J. Food Sci., 2011, 5(14), 780-789.
[http://dx.doi.org/10.5897/AJFS11.060]
[62]
Wichitnithad, W.; Jongaroonngamsang, N.; Pummangura, S.; Rojsitthisak, P. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochem. Anal., 2009, 20(4), 314-319.
[http://dx.doi.org/10.1002/pca.1129] [PMID: 19402187]
[63]
Long, Y.; Zhang, W.; Wang, F.; Chen, Z. Simultaneous determination of three curcuminoids in Curcuma longa L. by high performance liquid chromatography coupled with electrochemical detection. J. Pharm. Anal., 2014, 4(5), 325-330.
[http://dx.doi.org/10.1016/j.jpha.2013.10.002] [PMID: 29403896]
[64]
Allam, A.N.; Komeil, I.A.; Fouda, M.A.; Abdallah, O.Y. Preparation, characterization and in vivo evaluation of curcumin self-nano phospholipid dispersion as an approach to enhance oral bioavailability. Int. J. Pharm., 2015, 489(1-2), 117-123.
[http://dx.doi.org/10.1016/j.ijpharm.2015.04.067] [PMID: 25936626]
[65]
Karimfar, M.H.; Noorafshan, A.; Rashidiani-Rashidabadi, A.; Poostpasand, A.; Asadi-Golshan, R.; Abdollahifar, M.A.; Karbalay-Doust, S. Curcumin prevents the structural changes induced in the rats’ deep cerebellar nuclei by sodium metabisulfite, a preservative agent. Asian Pac. J. Trop. Med., 2014, 7S1, S301-S305.
[http://dx.doi.org/10.1016/S1995-7645(14)60250-9] [PMID: 25312141]
[66]
Ghosh, S.; Bhattacharyya, S.; Rashid, K.; Sil, P.C. Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways. Toxicol. Rep., 2015, 2, 365-376.
[http://dx.doi.org/10.1016/j.toxrep.2014.12.017] [PMID: 28962370]
[67]
Gazal, M.; Valente, M.R.; Acosta, B.A.; Kaufmann, F.N.; Braganhol, E.; Lencina, C.L.; Stefanello, F.M.; Ghisleni, G.; Kaster, M.P. Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats. Eur. J. Pharmacol., 2014, 724, 132-139.
[http://dx.doi.org/10.1016/j.ejphar.2013.12.028] [PMID: 24384407]
[68]
Mondal, G.; Barui, S.; Saha, S.; Chaudhuri, A. Tumor growth inhibition through targeting liposomally bound curcumin to tumor vasculature. J. Control. Release, 2013, 172(3), 832-840.
[http://dx.doi.org/10.1016/j.jconrel.2013.08.302] [PMID: 24036260]
[69]
Firouzi, Z.; Lari, P.; Rashedinia, M.; Ramezani, M.; Iranshahi, M.; Abnous, K. Proteomics screening of molecular targets of curcumin in mouse brain. Life Sci., 2014, 98(1), 12-17.
[http://dx.doi.org/10.1016/j.lfs.2013.12.200] [PMID: 24394958]
[70]
Sebastià, N.; Montoro, A.; Hervás, D.; Pantelias, G.; Hatzi, V.I.; Soriano, J.M.; Villaescusa, J.I.; Terzoudi, G.I. Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay. Mutat. Res., 2014, 766-767, 49-55.
[http://dx.doi.org/10.1016/j.mrfmmm.2014.05.006] [PMID: 25847272]
[71]
Jayakumar, S.; Gomathi, T.; Sudha, P.N. Sorption studies of lead (II) onto crosslinked and non crosslinked biopolymeric blends. Int. J. Biol. Macromol., 2013, 59, 165-169.
[http://dx.doi.org/10.1016/j.ijbiomac.2013.04.031] [PMID: 23603073]
[72]
Dey, S.; Sreenivasan, K. Conjugation of curcumin onto alginate enhances aqueous solubility and stability of curcumin. Carbohydr. Polym., 2014, 99, 499-507.
[http://dx.doi.org/10.1016/j.carbpol.2013.08.067] [PMID: 24274536]
[73]
Birdane, L.; San, T.; Muluk, N.B.; Burukoglu, D.; Cingi, C. Efficacy of Curcumin in the healing of paracentesis in rats. Int. J. Pediatr. Otorhinolaryngol., 2014, 78(2), 280-284.
[http://dx.doi.org/10.1016/j.ijporl.2013.11.024] [PMID: 24355767]
[74]
Samaan, N.; Zhong, Q.; Fernandez, J.; Chen, G.; Hussain, A.M.; Zheng, S.; Wang, G.; Chen, Q.H. Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents. Eur. J. Med. Chem., 2014, 75, 123-131.
[http://dx.doi.org/10.1016/j.ejmech.2014.01.041] [PMID: 24531225]