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Current Pharmaceutical Design

Author(s): Yuanjin Gong, Chang Chang, Xi Liu, Yan He*, Yiqi Wu*, Song Wang and Chongyou Zhang

DOI: 10.2174/1381612826666200610183048

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Stimulator of Interferon Genes Signaling Pathway and its Role in Anti-tumor Immune Therapy

Page: [3085 - 3095] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Stimulator of interferon genes is an important innate immune signaling molecule in the body and is involved in the innate immune signal transduction pathway induced by pathogen-associated molecular patterns or damage-associated molecular patterns. Stimulator of interferon genes promotes the production of type I interferon and thus plays an important role in the innate immune response to infection. In addition, according to a recent study, the stimulator of interferon genes pathway also contributes to anti-inflammatory and anti-tumor reactions. In this paper, current researches on the Stimulator of interferon genes signaling pathway and its relationship with tumor immunity are reviewed. Meanwhile, a series of critical problems to be addressed in subsequent studies are discussed as well.

Keywords: STING, innate immune response, type I interferon, cGAMP, cGAS, anti-tumor immunity.

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