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Current Alzheimer Research

Author(s): Robson B. Teixeira, Paulo Roberto dos Santos Amorim, João C.B. Marins, Yuri de L.X. Martins, Samuel de Souza Magalhães Marques, Victor P.R. Aguiar, András Palotás* and Luciana M. Lima*

DOI: 10.2174/1567205017666200522205646

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Physical Inactivity is Liable to the Increased Cardiovascular Risk and Impaired Cognitive Profile

Page: [365 - 372] Pages: 8

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Abstract

Background: Sedentary life-style is a significant public health issue. It increases the incidence of type-2 diabetes mellitus (DM2) and systemic arterial hypertension (SAH), which in turn may impair physical and mental health. In fact, disrupted glucose metabolism is characteristic of Alzheimer’s dementia, and it is often dubbed as type-3 diabetes.

Objective: The purpose of this study was to assess the level of activity, body composition, cardiovascular risk and cognitive profile of patients with DM2 and/or SAH. The study was cross-sectional design.

Method: The sample consisted of 120 individuals which 35% men and 65% women, with an average of 64±9 years old and 60±11 years old, respectively. Various parameters were evaluated such as anthropometric variables, pedometer recordings and brief cognitive screening battery (BCSB), which assesses the immediate memory, verbal fluency, learning, late memory and recognition. Chi-square and Fisher's exact test were applied to observe possible differences between men and women. In addition to Kruskall-Wallis, in the comparison between patients with SAH; DM2 and SAH + DM2.

Results: A high rate of physical inactivity was found among those enrolled in this project. Females were characterized by increased body fat, whereas men displayed visceral fat excess. BCSB demonstrated reduced verbal fluency, late memory and recognition, with women presenting significantly worse results.

Conclusion: Low level of daily physical activity is apparently correlated with obesity, elevated cardiovascular risk, and cognitive dysfunction.

Keywords: Brief cognitive screening battery (BCSB), cognition, diabetes, hypertension, inactivity, memory, physical activity, sedentary life-style.

[1]
Muriach M, Flores-Bellver M, Romero FJ, Barcia JM. Diabetes and the brain: oxidative stress, inflamemation, and autophagy. Oxid Med Cell Longev 2014; 2014; 102158.
[2]
Milne NT, Bucks RS, Davis WA, et al. Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus. Brain Behav 2017; 8(1)e00741
[http://dx.doi.org/10.1002/brb3.741] [PMID: 29568674]
[3]
Takeda JRT, Matos TM, de Souza-Talarico JN. Cardiovascular risk factors and cognitive performance in aging. Dement Neuropsychol 2017; 11(4): 442-8.
[http://dx.doi.org/10.1590/1980-57642016dn11-040015] [PMID: 29354226]
[4]
Böhm M, Schumacher H, Leong D, et al. Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk. Hypertension 2015; 65(3): 651-61.
[5]
Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: Molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ 2014; 38(4): 308-14.
[http://dx.doi.org/10.1152/advan.00080.2014] [PMID: 25434013]
[6]
Jia LL, Kang YM, Wang FX, et al. Exercise training attenuates hypertension and cardiac hypertrophy by modulating neurotransmitters and cytokines in hypothalamic paraventricular nucleus. PLoS One 2014; 9(1):e85481
[http://dx.doi.org/10.1371/journal.pone.0085481] [PMID: 24482680]
[7]
Lade C, Marins JCB, Lima L, Albuquerque M, Teixeira R, Reis J. Nível de atividade física habitual em portadores e não portadores de neuropatia diabética. RBAFS 2016; 21(4): 324-33.
[http://dx.doi.org/10.12820/rbafs.v.21n4p324-333]
[8]
Teixeira RB, Marins JCB, Amorim PRS, et al. Evaluating the effects of exercise on cognitive function in hypertensive and diabetic patients using the mental test and training system. World J Biol Psychiatry 2019; 20(3): 209-18.
[PMID: 28657472]
[9]
Antunes HKM, Santos-Galduroz RF, De Aquino Lemos V, et al. The influence of physical exercise and leisure activity on neuropsychological functioning in older adults. Age (Dordr) 2015; 37(4): 9815.
[http://dx.doi.org/10.1007/s11357-015-9815-8] [PMID: 26169946]
[10]
Hameed MA, Dasgupta I. Medication adherence and treatment-resistant hypertension: A review. Drugs Context 2019; 8212:560.
[http://dx.doi.org/10.7573/dic.212560] [PMID: 30774692]
[11]
Corder K, Ekelund U, Steele RM, Wareham NJ, Brage S. Assessment of physical activity in youth. J Appl Physiol 2008; 105(3): 977-87.
[http://dx.doi.org/10.1152/japplphysiol.00094.2008] [PMID: 18635884]
[12]
Tudor-Locke C, Hatano Y, Pangrazi RP, Kang M. Revisiting “how many steps are enough?”. Med Sci Sports Exerc 2008; 40(7): S537-43.
[http://dx.doi.org/10.1249/MSS.0b013e31817c7133] [PMID: 18562971]
[13]
Nitrini R, Lefèvre BH, Mathias SC, et al. Testes neuropsicológicos de aplicação simples para o diagnóstico de demência. Arq Neuropsiquiatr 1994; 52(4): 457-65.
[http://dx.doi.org/10.1590/S0004-282X1994000400001] [PMID: 7611936]
[14]
Valdez R. A simple model-based index of abdominal adiposity. J Clin Epidemiol 1991; 44(9): 955-6.
[http://dx.doi.org/10.1016/0895-4356(91)90059-I] [PMID: 1890438]
[15]
Ashwell M, Hsieh SD. Six reasons why the waist-to-height ratio is a rapid and effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity. Int J Food Sci Nutr 2005; 56(5): 303-7.
[http://dx.doi.org/10.1080/09637480500195066] [PMID: 16236591]
[16]
Bergman RN, Stefanovski D, Buchanan TA, et al. A better index of body adiposity. Obesity (Silver Spring) 2011; 19(5): 1083-9.
[http://dx.doi.org/10.1038/oby.2011.38] [PMID: 21372804]
[17]
Motamed N, Rabiee B, Hemasi GR, et al. Body roundness index and waist-to-height ratio are strongly associated with non-alcoholic fatty liver disease: A population-based study. Hepat Mon 2016; 16(9)e39575
[http://dx.doi.org/10.5812/hepatmon.39575] [PMID: 27822266]
[18]
World Health Organization. Physical status: The use and interpretation of anthropometry Report of a WHO Expert Committee. Geneva: World Health Organization 1995.
[19]
Marfell-Jones M, Olds T, Stewart AA. International standards foanthropometric assessment International Society for the Advancement of KinanthropometryISAK 2006.
[20]
Tyburski E, Sokołowski A, Chęć M, Pełka-Wysiecka J, Samochowiec A. Neuropsychological characteristics of verbal and non-verbal fluency in schizophrenia patients. Arch Psychiatr Nurs 2015; 29(1): 33-8.
[http://dx.doi.org/10.1016/j.apnu.2014.09.009] [PMID: 25634872]
[21]
Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer’s disease: Successive emergence of the clinical symptoms. Ann Neurol 2008; 64(5): 492-8.
[PMID: 19067364]
[22]
Santini E, Huynh TN, Klann E. Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory. Prog Mol Biol Transl Sci 2014; 122: 131-67.
[http://dx.doi.org/10.1016/B978-0-12-420170-5.00005-2] [PMID: 24484700]
[23]
Pitsikas N. The role of nitric oxide in the object recognition memory. Behav Brain Res 2015; 285: 200-7.
[http://dx.doi.org/10.1016/j.bbr.2014.06.008] [PMID: 24933185]
[24]
Terrera GM, Minett T, Brayne C, Matthews FE. Education associated with a delayed onset of terminal decline. Age Ageing 2014; 43(1): 26-31.
[http://dx.doi.org/10.1093/ageing/aft150] [PMID: 24136340]
[25]
De Silva TM, Faraci FM. Microvascular dysfunction and cognitive impairment. Cell Mol Neurobiol 2016; 36(2): 241-58.
[http://dx.doi.org/10.1007/s10571-015-0308-1] [PMID: 26988697]
[26]
De Felice FG, Lourenco MV, Ferreira ST. How does brain insulin resistance develop in Alzheimer’s disease? Alzheimers Dement 2014; 10(1): S26-32.
[PMID: 24529521]
[27]
Gottesman RF, Schneider AL, Albert M, et al. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study. JAMA Neurol 2014; 71(10): 1218-27.
[PMID: 25090106]
[28]
Muela HC, Costa-hong VA, Machado MF, et al. Hypertension Severity is Associated With Impaired Cognitive Performance. Circulation 2015; 132(3):A17612.
[29]
Willette AA, Bendlin BB, Starks EJ, et al. Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurol 2015; 72(9): 1013-20.
[http://dx.doi.org/10.1001/jamaneurol.2015.0613] [PMID: 26214150]
[30]
Neergaard JS, Dragsbæk K, Christiansen C, et al. Metabolic syndrome, insulin resistance, and cognitive dysfunction: Does your metabolic profile affect your brain? Diabetes 2017; 66(7): 1957-63.
[http://dx.doi.org/10.2337/db16-1444] [PMID: 28389469]
[31]
Kim M, Park JM. Factors affecting cognitive function according to gender in community-dwelling elderly individuals. Epidemiol Health 2017; 39,e2017054.
[http://dx.doi.org/10.4178/epih.e2017054] [PMID: 29141399]
[32]
Reas ET, Laughlin GA, Bergstrom J, et al. Efeitos do sexo e da educação na mudança cognitiva em um período de 27 anos em idosos: o estudo de Rancho Bernardo. Am J Geriatr Psychiatry 2017; 25(8): 889-99.
[http://dx.doi.org/10.1016/j.jagp.2017.03.008] [PMID: 28433548]
[33]
Maldonado-Ruiz R, Montalvo-Martínez L, Fuentes-Mera L, Camacho A. Microglia activation due to obesity programs metabolic failure leading to type two diabetes. Nutr Diabetes 2017; 7(3): e254.
[http://dx.doi.org/10.1038/nutd.2017.10] [PMID: 28319103]
[34]
Bielemann RM, Silva BGCD, Coll CdeV, Xavier MO, Silva SGD. Burden of physical inactivity and hospitalization costs due to chronic diseases. Rev Saude Publica 2015; 49: 75.
[http://dx.doi.org/10.1590/S0034-8910.2015049005650] [PMID: 26487291]
[35]
Xu X, Parker D, Shi Z, Byles J, Hall J, Hickman L. Dietary pattern, hypertension and cognitive function in an older population: 10-year longitudinal survey. Front Public Health 2018; 6: 201.
[http://dx.doi.org/10.3389/fpubh.2018.00201] [PMID: 30079333]
[36]
de Rezende LFM, Rey-López JP, Matsudo VKR, do Carmo Luiz O. Sedentary behavior and health outcomes among older adults: A systematic review. BMC Public Health 2014; 14(1): 333.
[http://dx.doi.org/10.1186/1471-2458-14-333] [PMID: 24712381]
[37]
Rawlings AM, Sharrett AR, Schneider AL, et al. Diabetes in midlife and cognitive change over 20 years: a cohort study. Ann Intern Med 2014; 161(11): 785-93.
[PMID: 25437406]