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Current Bioactive Compounds

Author(s): Monika Targhotra*, Rohan Aggarwal and Meenakshi K. Chauhan

DOI: 10.2174/1573407216999200518090132

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Bioactive Compounds for Effective Management of Drug-Resistant Tuberculosis

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Abstract

Background: Tuberculosis is a granulomatous irresistible bacterial infection caused by Mycobacterium tuberculosis. The present anti-TB antibiotics are less useful in the treatment of Multi- Drug-Resistant (MDR) strains.

Methods: We focused on distinguishing phyto-bioactive compounds dependent on customary uses and testing their concentrates against MDR strains. This will help abbreviate the present remedial regimens for TB and for treating HIV-TB co-disease.

Results: This article is an endeavor to examine the antimycobacterial and immunomodulatory role of phyto-bioactive compounds as another option and feature them for additional examination for the management of drug-resistant tuberculosis.

Conclusion: This review focused on the tubercle bacilli utilizing bioactive compounds as the therapeutic vehicle against MDR strains and also the synergistic action with available TB medications.

Keywords: Tuberculosis, mycobacterium, isoniazid, MDR, phyto-bioactive, natural, antimycobacterial.

Graphical Abstract

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