Abstract

The isolation, structure determination and biological evaluation of the eudistomin alkaloids, isolated mainly from marine tunicates of the genus Eudistoma, is described. The compounds are placed in a well defined unique structural class based upon biogenic considerations. The methods which have been employed towards total synthesis of these metabolites are reviewed in detail.

Keywords: Eudistomin marine alkaloids, Marine tunicates, Eudistoma, Marine natural products, Anticancer, Antibacterial, Antiviral activities, Dolabella, Auricularia, Bugula neritina, Ecteinascidia, Cancer, Lissoclinum fragile, Pseudodistoma aureum, Synthesis, Cysteine derived, Eudistomins, Eudistomidins, Glutamate, Proline derived, Beta carbolines