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Current Organic Synthesis

Author(s): Marcel L. Almeida, Maria C.V.A. Oliveira, Ivan R. Pitta and Marina G.R. Pitta *

DOI: 10.2174/1570179417666200325124712

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Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide

Page: [252 - 270] Pages: 19

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Abstract

Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.

Keywords: Phthalimide, thalidomide, medicinal chemistry, anti-tumor, anti-inflammatory, antimicrobial.

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