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Anti-Cancer Agents in Medicinal Chemistry

Author(s): Xiao-Yi Kuai, Zhi-Yi Lei*, Xiao-Shuang Liu and Xin-Yu Shao*

DOI: 10.2174/1871520620666200318094618

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The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer

Page: [941 - 950] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Background: Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underlying mechanism of the altered metabolism in CRC is still unknown.

Methods: In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in 135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated.

Results: Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1 showed a significantly strong link with FOXM1 in CRC tissue.

Conclusion: Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.

Keywords: Colorectal cancer, FOXM1, GLUT1, prognosis, altered metabolism, immunohistochemical staining.

Graphical Abstract

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