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Current Pharmaceutical Design

Author(s): Md. A. Barkat, Harshita, Md. Rizwanullah, Faheem H. Pottoo, Sarwar Beg, Sohail Akhter* and Farhan J. Ahmad

DOI: 10.2174/1381612826666200317140600

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Therapeutic Nanoemulsion: Concept to Delivery

Page: [1145 - 1166] Pages: 22

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Abstract

Nanoemulsions (NEs) or nanometric-scaled emulsions are transparent or translucent, optically isotropic and kinetically stable heterogeneous system of two different immiscible liquids namely, water and oil stabilized with an amphiphilic surfactant having droplet size ranges up to 100 nm. They offer a variety of potential interests for certain applications: improved deep-rooted stability; excellent optical clarity; and, enhanced bioavailability due to its nanoscale of particles. Though there is still comparatively narrow insight apropos design, development, and optimization of NEs, which mainly stems from the fact that conventional characteristics of emulsion development and stabilization only partly apply to NEs. The contemporary article focuses on the nanoemulsion dosage form journey from concept to key application in drug delivery. In addition, industrial scalability of the nanoemulsion, as well as its presence in commercial and clinical practice, are also addressed.

Keywords: Nanoemulsions, Nanometric-scaled emulsions, kinetically stable, Bioavailability, Drug delivery, amphiphilic surfactant.

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