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Current Pharmaceutical Design

Author(s): Yue Shi, Jiayuan Qu, Liyue Gai, Ding Yuan* and Chengfu Yuan*

DOI: 10.2174/1381612826666200316143842

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Long Non-coding RNAs in Metabolic and Inflammatory Pathways in Obesity

Page: [3317 - 3325] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Background: In recent decades, the incidence of obesity has been rising globally. Obesity can often cause various inflammatory reactions, resulting in several diseases that threaten public health. The purpose of this review is to explore the role of long non-coding RNAs in metabolic obesity and find new targets for the prevention and treatment of metabolic diseases.

Methods: We described the relationship between obesity and inflammation, reviewed several signaling pathways in metabolic inflammation, and summarized some of the long non-coding RNAs and their targets associated with metabolic inflammation. The related studies were retrieved through a systematic search of the PubMed database.

Result: Metabolic stress during obesity can cause inflammation through several metabolic pathways. Many long non-coding RNAs can affect the progression of metabolic inflammation by affecting different pathways.

Conclusion: Downregulation or antagonization of long non-coding RNAs in metabolic pathways may provide new ideas and therapeutic targets for the prevention and treatment of metabolic inflammation.

Keywords: Metabolic inflammation, signaling pathway, long non-coding RNA, obesity, inflammation, metabolic stress.

[1]
Fergus EC. Obesity: unrecognised or avoided We are missing opportunities to ‘make every contact count’. Archives of Disease in Childhood 2019.archdischild-2019-317734.
[2]
Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 2008; 16(10): 2323-30.
[http://dx.doi.org/10.1038/oby.2008.351] [PMID: 18719634]
[3]
Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab 2004; 89(6): 2583-9.
[http://dx.doi.org/10.1210/jc.2004-0535] [PMID: 15181027]
[4]
Ringseis R, Eder K, Mooren FC, Krüger K. Metabolic signals and innate immune activation in obesity and exercise. Exerc Immunol Rev 2015; 21: 58-68.
[PMID: 25825956]
[5]
Kleemann R, van Erk M, Verschuren L, et al. Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance. PLoS One 2010; 5(1) e8817
[http://dx.doi.org/10.1371/journal.pone.0008817] [PMID: 20098690]
[6]
Chowdhury IH, Narra HP, Sahni A, Khanipov K, Fofanov Y, Sahni SK. Enhancer Associated Long Non-coding RNA Transcription and Gene Regulation in Experimental Models of Rickettsial Infection. Front Immunol 2019; 9: 3014.
[http://dx.doi.org/10.3389/fimmu.2018.03014] [PMID: 30687302]
[7]
Bondia-Pons I, Ryan L, Martinez JA. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 2012; 68(4): 701-11.
[http://dx.doi.org/10.1007/s13105-012-0154-2] [PMID: 22351038]
[8]
Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117(1): 175-84.
[http://dx.doi.org/10.1172/JCI29881] [PMID: 17200717]
[9]
Bhargava P, Lee CH. Role and function of macrophages in the metabolic syndrome. Biochem J 2012; 442(2): 253-62.
[http://dx.doi.org/10.1042/BJ20111708] [PMID: 22329799]
[10]
Liu G, Bei J, Liang L, Yu G, Li L, Li Q. Stachyose Improves Inflammation Through Modulating Gut Microbiota of HighFat Diet / Streptozotocin Induced Type 2 Diabetes in Rats. 2018; 62(6) :1700954.
[11]
Schappe MS, Szteyn K, Stremska ME, et al. Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation. Immunity 2018; 48(1): 59-74.e5.
[http://dx.doi.org/10.1016/j.immuni.2017.11.026] [PMID: 29343440]
[12]
Enos RT, Velázquez KT, Murphy EA. Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. J Nutr Biochem 2014; 25(6): 600-12.
[http://dx.doi.org/10.1016/j.jnutbio.2014.01.011] [PMID: 24742471]
[13]
Neymotin F, Nemzer LR. Locus of Control and Obesity. Front Endocrinol 2014.
[http://dx.doi.org/10.3389/fendo.2014.00159]]
[14]
Lee B-C, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta 2014; 1842(3): 446-62.
[http://dx.doi.org/10.1016/j.bbadis.2013.05.017] [PMID: 23707515]
[15]
Dali-Youcef N, Ricci R. Signalling Networks Governing Metabolic Inflammation. Handb Exp Pharmacol 2016; 233: 195-220.
[http://dx.doi.org/10.1007/164_2015_4] [PMID: 25903413]
[16]
Chuang HC, Wang X, Tan TH. MAP4K Family Kinases in Immunity and Inflammation. Adv Immunol 2016; 129: 277-314.
[http://dx.doi.org/10.1016/bs.ai.2015.09.006] [PMID: 26791862]
[17]
Kumar A, Singh UK, Kini SG, et al. JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases. Future Med Chem 2015; 7(15): 2065-86.
[http://dx.doi.org/10.4155/fmc.15.132] [PMID: 26505831]
[18]
Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001; 22(2): 153-83.
[PMID: 11294822]
[19]
Rodriguez Lanzi C, Perdicaro DJ, Landa MS, et al. Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes. J Nutr Biochem 2018; 56(11): 224-33.
[http://dx.doi.org/10.1016/j.jnutbio.2018.03.001] [PMID: 29631143]
[20]
Han MS, Barrett T, Brehm MA, Davis RJ. Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Rep 2016; 15(1): 19-26.
[http://dx.doi.org/10.1016/j.celrep.2016.03.008] [PMID: 27052181]
[21]
Wulczyn FG, Krappmann D, Scheidereit C. The NF-κ B/Rel and I κ B gene families: mediators of immune response and inflammation. J Mol Med (Berl) 1996; 74(12): 749-69.
[http://dx.doi.org/10.1007/s001090050078] [PMID: 8974017]
[22]
Mohammadi A, Sahebkar A, Iranshahi M, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 2013; 27(3): 374-9.
[http://dx.doi.org/10.1002/ptr.4715] [PMID: 22610853]
[23]
Gao LN, Feng QS, Zhang XF, Wang QS, Cui YL. Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation. J Orthop Res 2016; 34(9): 1557-68.
[http://dx.doi.org/10.1002/jor.23155] [PMID: 26748661]
[24]
Diaz-Meco MT, Moscat J. The atypical PKCs in inflammation: NF-κB and beyond. Immunol Rev 2012; 246(1): 154-67.
[http://dx.doi.org/10.1111/j.1600-065X.2012.01093.x] [PMID: 22435553]
[25]
Wong ET, Tergaonkar V. Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential. Clin Sci (Lond) 2009; 116(6): 451-65.
[http://dx.doi.org/10.1042/CS20080502] [PMID: 19200055]
[26]
Leppänen T, Tuominen RK, Moilanen E. Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example. Basic Clin Pharmacol Toxicol 2014; 114(1): 37-43.
[http://dx.doi.org/10.1111/bcpt.12139] [PMID: 24107256]
[27]
Tobias I. Molecular Mechanisms of Atypical Protein Kinase C Regulation in Insulin Signaling (Doctoral dissertation, UC San Diego) 2016.
[28]
Hirai T, Chida K. Protein Kinase Cζ (PKCζ). Activation Mechanisms and Cellular Functions 2003; 133(1): 1-7.
[PMID: 12932816]
[29]
Kang JH, Toita R, Kim CW, Katayama Y. Protein kinase C (PKC) isozyme-specific substrates and their design. Biotechnol Adv 2012; 30(6): 1662-72.
[http://dx.doi.org/10.1016/j.biotechadv.2012.07.004] [PMID: 22841933]
[30]
Meng Q, Xia Y. c-Jun, at the crossroad of the signaling network. Protein Cell 2011; 2(11): 889-98.
[http://dx.doi.org/10.1007/s13238-011-1113-3] [PMID: 22180088]
[31]
Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annual Rev Nutr 2010; 30: 173-99.
[http://dx.doi.org/10.1146/annurev.nutr.012809.104755]
[32]
Kim MS, Lim WK, Cha JG, et al. The activation of PI 3-K and PKC ζ in PMA-induced differentiation of HL-60 cells. Cancer Lett 2001; 171(1): 79-85.
[http://dx.doi.org/10.1016/S0304-3835(01)00505-5] [PMID: 11485830]
[33]
Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE. Atypical protein kinase C (PKCzeta/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol 2004; 164(2): 279-90.
[http://dx.doi.org/10.1083/jcb.200306152] [PMID: 14734537]
[34]
Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet 2014; 15(1): 7-21.
[http://dx.doi.org/10.1038/nrg3606] [PMID: 24296535]
[35]
Li H, Yu B, Li J, et al. Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. Oncotarget 2014; 5(8): 2318-29.
[http://dx.doi.org/10.18632/oncotarget.1913] [PMID: 24810858]
[36]
Chu C, Qu K, Zhong FL, Artandi SE, Chang HY. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell 2011; 44(4): 667-78.
[http://dx.doi.org/10.1016/j.molcel.2011.08.027] [PMID: 21963238]
[37]
Arita T, Ichikawa D, Konishi H, et al. Circulating long non-coding RNAs in plasma of patients with gastric cancer. Anticancer Res 2013; 33(8): 3185-93.
[PMID: 23898077]
[38]
Geng C, Wang Z, Wang D, et al. LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res 2012; (D1): D1.
[PMID: 23175614]
[39]
Kotzin JJ, Spencer SP, McCright SJ. Kumar, Dinesh B. Uthaya, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 2016; (239-243): 537.
[40]
Chen X, Yan G-Y. Novel human lncRNA-disease association inference based on lncRNA expression profiles. Bioinformatics 2013; 29(20): 2617-24.
[http://dx.doi.org/10.1093/bioinformatics/btt426] [PMID: 24002109]
[41]
Sathishkumar C, Prabu P, Mohan V, Balasubramanyam M. Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes. Hum Genomics 2018; 12(1): 41.
[http://dx.doi.org/10.1186/s40246-018-0173-3] [PMID: 30139387]
[42]
Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell 2011; 43(6): 904-14.
[http://dx.doi.org/10.1016/j.molcel.2011.08.018] [PMID: 21925379]
[43]
Chen J, Liu Y, Lu S, et al. The role and possible mechanism of lncRNA U90926 in modulating 3T3-L1 preadipocyte differentiation. Int J Obes 2017; 41(2): 299-308.
[http://dx.doi.org/10.1038/ijo.2016.189] [PMID: 27780975]
[44]
Cui X, You L, Li Y, et al. A transcribed ultraconserved noncoding RNA, uc.417, serves as a negative regulator of brown adipose tissue thermogenesis. FASEB J 2016; 30(12): 4301-12.
[http://dx.doi.org/10.1096/fj.201600694R] [PMID: 27655899]
[45]
Fang YX, Zou Y, Wang GT, Huang SH, Zhou YJ, Zhou YJ. lnc TINCR induced by NOD1 mediates inflammatory response in 3T3-L1 adipocytes. Gene 2019; 698: 150-6.
[