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Letters in Organic Chemistry

Author(s): Ch. Venkata Ramana Reddy* and G. Ganga Reddy

DOI: 10.2174/1570178617666200225110402

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Simple, Stepwise and Alternative Syntheses of Indolyl Triazoles via Huisgen,s 1, 3-dipolar Cycloaddition Reaction

Page: [187 - 194] Pages: 8

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Abstract

A series of new 2-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)1H-indol- 3-yl)me thylene)malononitrile derivatives were synthesized by the 1,3-dipolar cycloaddition reaction (click reaction) of 2-((1-(prop-2-yn-1-yl)-1H-indol-3-yl)methylene)malononitrile with different aryl azides in the presence of sodium ascorbate and copper sulphate in good yields. The advantages of this method are efficient, clean, high yields, easy workup procedures, and shorter reaction time. These reactions are very facile, giving products by simple processing that does not require purification by column chromatography. Spectroscopic methods confirmed all the newly synthesized compounds.

Keywords: Knoevengal condensation, 1, 2, 3-triazole, N-propargylation, click chemistry, Aryl azides, step-wise synthesis and alternative synthesis.

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