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Current Drug Delivery

Author(s): Lanke Tejesh Varma, Nidhi Singh, Bapi Gorain, Hira Choudhury, Murtaza M. Tambuwala, Prashant Kesharwani* and Rahul Shukla*

DOI: 10.2174/1567201817666200210122340

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Recent Advances in Self-Assembled Nanoparticles for Drug Delivery

Page: [279 - 291] Pages: 13

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Abstract

The collection of different bulk materials forms the nanoparticles, where the properties of the nanoparticle are solely different from the individual components before being ensembled. Selfassembled nanoparticles are basically a group of complex functional units that are formed by gathering the individual bulk components of the system. It includes micelles, polymeric nanoparticle, carbon nanotubes, liposomes and niosomes, etc. This self-assembly has progressively heightened interest to control the final complex structure of the nanoparticle and its associated properties. The main challenge of formulating self-assembled nanoparticle is to improve the delivery system, bioavailability, enhance circulation time, confer molecular targeting, controlled release, protection of the incorporated drug from external environment and also serve as nanocarriers for macromolecules. Ultimately, these self-assembled nanoparticles facilitate to overcome the physiological barriers in vivo. Self-assembly is an equilibrium process where both individual and assembled components are subsisting in equilibrium. It is a bottom up approach in which molecules are assembled spontaneously, non-covalently into a stable and welldefined structure. There are different approaches that have been adopted in fabrication of self-assembled nanoparticles by the researchers. The current review is enriched with strategies for nanoparticle selfassembly, associated properties, and its application in therapy.

Keywords: Self-assembly, driving forces, nanoparticle, mesoporous silica nanoparticle, gold nanoparticle, liposome.

Graphical Abstract

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