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Endocrine, Metabolic & Immune Disorders - Drug Targets

Author(s): Maysaa E.S. Zaki*, Sally Abed, Mohamed Elegezy, Muhammed Diasty, Nashwa Yousef Ebrahim Elkhouly, Ehab M. Fahmy and Nesreen M. Kamel

DOI: 10.2174/1871530320666200206120151

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Can Triggering Receptors Expressed on Myeloid Cells be used for Diagnosis of Salmonella Typhi Infection?

Page: [1488 - 1493] Pages: 6

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Abstract

Background: There is a need for rapid and accurate diagnostic biomarker for diagnosis of Salmonella fever.

Aims: The aim of the present study was to assess the importance of procalcitonin (PCT), Soluble Triggering Receptors expressed on Myeloid Cells 1 (sTREM1) and C- reactive protein (CRP) in the diagnosis of enteric fever with positive blood culture for S.typhi.

Methods: Blood samples were withdrawn from 200 patients with suspected enteric fever and subjected for the determination of CRP, PCT and sTREM-1.

Results: The sensitivity and specificity for PCT cut off were 97.7% & 82.5%, for CRP the sensitivity and specificity were 95.3% and 77% and for s-TREM-1 the sensitivity and specificity were 95.3% & 77%.

Conclusion: S-TREM-1 may be considered as a novel biomarker for the diagnosis of enteric fever with good sensitivity and specificity.

Keywords: Enteric fever, PCT, sTREM1, CRP, blood culture, ELISA.

Graphical Abstract

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