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Cardiovascular & Hematological Agents in Medicinal Chemistry

Author(s): Sangeethadevi Govindasami, Veera Venkata Sathibabu Uddandrao , Nivedha Raveendran and Vadivukkarasi Sasikumar *

DOI: 10.2174/1871525718666200206114304

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Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced Myocardial Infarction in Rats

Page: [31 - 36] Pages: 6

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Abstract

Background: This study determined the effect of Biochanin A (BCA) on isoproterenol (ISO) induced Myocardial Infarction (MI) in male Wistar rats.

Methods: Animals (weighing 150-180 g) were divided into four groups, with six animals in each group and pretreated with BCA (10mg/kg Body Weight [BW]) and ɑ-tocopherol (60mg/kg BW) for 30 days; and ISO (20mg/kg BW) was administrated subcutaneously on the 31st and 32nd day.

Results: ISO-induced MI rats demonstrated the significant elevation of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactate dehydrogenase, creatine kinase-MB and cardiac troponin; however, concomitant pretreatment with BCA protected the rats from cardiotoxicity caused by ISO. Activities of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase significantly reduced in the heart with ISO-induced MI. Pretreatment with BCA produced a marked reversal of these antioxidant enzymes related to MI-induced by ISO.

Conclusion: In conclusion, this study suggested that BCA exerts cardioprotective effects through modulating lipid peroxidation, enhancing antioxidants, and detoxifying enzyme systems.

Keywords: Biochanin A, cardiac markers, isoproterenol, myocardium, natural products, antioxidant enzymes.

Graphical Abstract

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