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Current Drug Discovery Technologies

Author(s): Fatemeh Sadat Hasheminasab, Fariba Sharififar, Seyed Mehdi Hashemi and Mohammad Setayesh*

DOI: 10.2174/1570163817666200203110803

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An Evidence-Based Research on Botanical Sources for Oral Mucositis Treatment in Traditional Persian Medicine

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Abstract

Background: Cancer is one of the most prevalent diseases associated with heavy complications in treatment. Mucotoxic cancer therapies such as head and neck radiotherapy and some of the chemotherapy agents may lead to oral mucositis. In addition to its economic consequences, mucositis also affects patients' quality of life. In Traditional Persian Medicine (TPM) manuscripts, several medicaments have been suggested for the treatment of mucositis.

Objective: Considering the public welcome for herbal medicine, the current evidence-based review study is conducted to investigate the herbal remedies which have been proposed for oral mucositis in TPM.

Methods: At first, a comprehensive survey was done on Qanon fi al-Teb, which is the most important textbook of TPM; then the scientific name of the herbs was authenticated according to the botanical textbooks. At last, data banks including Scopus, Pubmed, Web of science and Science direct were investigated for possible relevant properties of each medicinal plant in the literature.

Results: In total, 30 herbs are introduced in this study. According to the registered documents, 18 herbs are reported to have antioxidant, anti-inflammatory, antimicrobial, anti-nociceptive and wound healing properties of which the therapeutic effect of only a few herbs including Glycyrrhiza glabra, Malva sylvestris, Morus nigra, Punica granatum, and Solanum nigrum were directly evaluated against oral mucositis on the literature.

Conclusion: Despite the lack of human studies on mucositis for the other discussed herbs, their related pharmacological properties can be considered for new natural drug discovery supported by medieval and traditional experiments.

Keywords: Mucositis, traditional persian medicine, medicinal plants, cancer, chemotherapy, radiotherapy

Graphical Abstract

[1]
Sonis ST, Elting LS, Keefe D, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 2004; 100(Suppl. 9): 1995-2025.
[http://dx.doi.org/10.1002/cncr.20162] [PMID: 15108222]
[2]
Sonis ST, Oster G, Fuchs H, et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol 2001; 19(8): 2201-5.
[http://dx.doi.org/10.1200/JCO.2001.19.8.2201] [PMID: 11304772]
[3]
Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB. The burdens of cancer therapy: Clinal and economic outcomes of chemotherapy-induced mucositis. Cancer 2003; 98(7): 1531-9.
[http://dx.doi.org/10.1002/cncr.11671] [PMID: 14508842]
[4]
Rubenstein EB, Peterson DE, Schubert M, et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 2004; 100(Suppl. 9): 2026-46.
[http://dx.doi.org/10.1002/cncr.20163] [PMID: 15108223]
[5]
Nayebi N, Khalili N, Kamalinejad M, Emtiazy M. A systematic review of the efficacy and safety of Rosa damascena Mill. with an overview on its phytopharmacological properties. Complement Ther Med 2017; 34: 129-40.
[http://dx.doi.org/10.1016/j.ctim.2017.08.014] [PMID: 28917365]
[6]
Setayesh M, Zargaran A, Sadeghifar AR, Salehi M, Rezaeizadeh H. New candidates for treatment and management of carpal tunnel syndrome (CTS) based on Avicenna’s teachings in the Canon of Medicine. Integr Med Res 2018.
[http://dx.doi.org/10.1016/j.imr.2018.02.003]
[7]
https://nccih.nih.gov/research/results/spotlight/032011.htm
[8]
https://nccih.nih.gov/health/cancer/complementary-integrative-research
[9]
Greenlee H, Balneaves LG, Carlson LE, et al. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr 2014; 2014(50): 346-58.
[http://dx.doi.org/10.1093/jncimonographs/lgu041] [PMID: 25749602]
[10]
Heydarirad G, Rezaeizadeh H, Choopani R, Mosavat SH, Ameri A. Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia: A randomized, open-label, active-controlled trial. J Integr Med 2017; 15(3): 201-8.
[http://dx.doi.org/10.1016/S2095-4964(17)60333-9] [PMID: 28494850]
[11]
Hashempur MH, Heydari M, Mosavat SH, Heydari ST, Shams M. Complementary and alternative medicine use in Iranian patients with diabetes mellitus. J Integr Med 2015; 13(5): 319-25.
[http://dx.doi.org/10.1016/S2095-4964(15)60196-0] [PMID: 26343103]
[12]
Salehi Nowbandegani A, Kiumarcy S, Rahmani F, et al. Ethnopharmacological knowledge of Shiraz and Fasa in Fars region of Iran for diabetes mellitus. J Ethnopharmacol 2015; 172: 281-7.
[http://dx.doi.org/10.1016/j.jep.2015.06.017] [PMID: 26113181]
[13]
Jabbari M, Hashempur MH, Razavi SZE, Shahraki HR, Kamalinejad M, Emtiazy M. Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: A randomized, double-blind, active-controlled trial. J Ethnopharmacol 2016; 188: 80-6.
[http://dx.doi.org/10.1016/j.jep.2016.04.035] [PMID: 27125590]
[14]
Pourahmad J. History of medical sciences in Iran. Iran J Pharm Res 2010; 93-9.
[15]
Moosavyzadeh A, Ghaffari F, Mosavat SH, et al. The medieval Persian manuscript of Afyunieh: The first individual treatise on the opium and addiction in history. J Integr Med 2018; 16(2): 77-83.
[http://dx.doi.org/10.1016/j.joim.2018.02.004] [PMID: 29526240]
[16]
Setayesh M, Zargaran A, Sadeghifar AR, Salehi M, Rezaeizadeh H. New candidates for treatment and management of carpal tunnel syndrome based on the Persian Canon of Medicine. Integr Med Res 2018; 7(2): 126-35.
[http://dx.doi.org/10.1016/j.imr.2018.02.003] [PMID: 29984174]
[17]
Hosseinkhani A, Sahragard A, Namdari A, Zarshenas MM. Botanical sources for Alzheimer’s: A review on reports from traditional Persian medicine. Am J Alzheimers Dis Other Demen 2017; 32(7): 429-37.
[http://dx.doi.org/10.1177/1533317517717013] [PMID: 28683559]
[18]
Jaladat AM, Atarzadeh F, Rezaeizadeh H, et al. Botanicals: an alternative remedy to radiotherapy-induced dysuria. Complement Ther Med 2015; 23(1): 90-9.
[http://dx.doi.org/10.1016/j.ctim.2014.11.004] [PMID: 25637157]
[19]
Mosavat SH, Marzban M, Bahrami M, Parvizi MM, Hajimonfarednejad M. Sexual headache from view point of Avicenna and traditional Persian medicine. Neurol Sci 2017; 38(1): 193-6.
[http://dx.doi.org/10.1007/s10072-016-2741-4] [PMID: 27770272]
[20]
Ibn-e-Sina A. Al-qanun fi-teb.The qanon of medicine. Beirut, Lebanon: Alaalami Beirut lib Press In: Beirut, Lebanon: Alaalami Beirut lib Press In: 2005.
[21]
Azam Khan M. Exir Azam Tehran: Institute of Medical History, Islamic medicine and complementary medicine 2008.
[22]
Heydari M, Heydari H, Saadati A, Gharehbeglou M, Tafaroji J, Akbari A. Ethnomedicine for neonatal jaundice: A cross-sectional survey in Qom, Iran. J Ethnopharmacol 2016; 193: 637-42.
[http://dx.doi.org/10.1016/j.jep.2016.10.019] [PMID: 27721052]
[23]
Hashempur MH, Khademi F, Rahmanifard M, Zarshenas MM. An evidence-based study on medicinal plants for hemorrhoids in Medieval Persia. J Evid Based Complementary Altern Med 2017; 22(4): 969-81.
[http://dx.doi.org/10.1177/2156587216688597] [PMID: 29228790]
[24]
Mahmoudvand H, Sharififar F, Rahmat MS, et al. Evaluation of antileishmanial activity and cytotoxicity of the extracts of Berberis vulgaris and Nigella sativa against Leishmania tropica. J Vector Borne Dis 2014; 51(4): 294-9.
[PMID: 25540961]
[25]
Pourgholamhossein F, Sharififar F, Rasooli R, et al. Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress. Environ Toxicol Pharmacol 2016; 45: 340-5.
[http://dx.doi.org/10.1016/j.etap.2016.06.019] [PMID: 27375216]
[26]
Sharififar F, Moshafi M, Shafazand E, Koohpayeh A. Acetyl cholinesterase inhibitory, antioxidant and cytotoxic activity of three dietary medicinal plants. Food Chem 2012; 130(1): 20-3.
[http://dx.doi.org/10.1016/j.foodchem.2011.06.034]
[27]
Mahmoudvand H, Tavakoli R, Sharififar F, et al. Leishmanicidal and cytotoxic activities of Nigella sativa and its active principle, thymoquinone. Pharm Biol 2015; 53(7): 1052-7.
[http://dx.doi.org/10.3109/13880209.2014.957784] [PMID: 25471014]
[28]
Ghamarian AR, Hajibabaei M, Javadi M. Physicians Desk Refrence Tehran: Clinical pharmacy Department, Tehran University of Medical Sciences 2011-2012.
[29]
Emami A, Ahi A. Medical botany. Tehran: Iran University of Medical Sciences and Health Services 2009.
[30]
Sonis ST. Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 2009; 45(12): 1015-20.
[http://dx.doi.org/10.1016/j.oraloncology.2009.08.006] [PMID: 19828360]
[31]
Harris DJ. Cancer treatment-induced mucositis pain: strategies for assessment and management. Ther Clin Risk Manag 2006; 2(3): 251-8.
[http://dx.doi.org/10.2147/tcrm.2006.2.3.251] [PMID: 18360600]
[32]
Miloro M, Ghali GE, Larsen P, Peterson LJ, Waite P. Peterson's principles of oral and maxillofacial surgery: PMPH-USA 2004.
[33]
Lalla RV, Bowen J, Barasch A, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2014; 120(10): 1453-61.
[http://dx.doi.org/10.1002/cncr.28592] [PMID: 24615748]
[34]
Sharififar F, Koohpayeh A, Motaghi MM, Amirkhosravi A, Puormohseni Nasab E, Khodashenas M. Study the ethnobotany of medicinal plants in Sirjan, Kerman province, Iran. J Herb Drugs 2010; 1(3): 19-28.
[35]
Mohamadi N, Sharififar F, Koohpayeh A, Daneshpajouh M. Traditional and Ethnobotanical uses of medicinal plants by ancient populations in Khabr and Rouchon of Iran. J Appl Pharm Sci 2015; 5(11): 101-7.
[http://dx.doi.org/10.7324/JAPS.2015.501117]
[36]
Mahmood T, Saeed S, Naveed I, Munir F, Raja GK. Assessment of antioxidative activities of extracts from selected Plantago species. J Med Plants Res 2011; 5(20): 5172-6.
[37]
Yakoob J, Jafri W, Mehmood MH, Abbas Z, Tariq K. Cytokine changes in gastric and colonic epithelial cell in response to Planta ovata extract. J Complement Integr Med 2017; 14(2)
[http://dx.doi.org/10.1515/jcim-2015-0075] [PMID: 28333654]
[38]
Motamedi H, Darabpour E, Gholipour M, Seyyed Nejad SM. Antibacterial effect of ethanolic and methanolic extracts of Plantago ovata and Oliveria decumbens endemic in Iran against some pathogenic bacteria. Int J Pharmacol 2010; 6(2): 117-22.
[http://dx.doi.org/10.3923/ijp.2010.117.122]
[39]
Kecmanovic DM, Pavlov MJ, Ceranic MS, Kerkez MD, Rankovic VI, Masirevic VP. Bulk agent Plantago ovata after Milligan-Morgan hemorrhoidectomy with Ligasure. Phytother Res 2006; 20(8): 655-8.
[http://dx.doi.org/10.1002/ptr.1926] [PMID: 16708408]
[40]
Bagheri SM, Zare-Mohazabieh F, Momeni-Asl H, Yadegari M, Mirjalili A, Anvari M. Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats. Biomed J 2018; 41(1): 41-5.
[http://dx.doi.org/10.1016/j.bj.2018.01.001] [PMID: 29673551]
[41]
Awaad Amani AS, Maitland DJ, Soliman GA. Antiulcerogenic Activity of Alhagi maurorum. Pharm Biol 2006; 44(4): 292-6.
[http://dx.doi.org/10.1080/13880200600714160]
[42]
Neamah NF. A pharmacological evaluation of aqueous extract of Alhagi maurorum. Glob J Pharmacol 2012; 6(1): 41-6.
[43]
Ahmad N, Shinwari ZK, Hussain J, Perveen R. Phytochemicals, antibacterial and antioxidative investigations of alhagi maurorum medik. Pak J Bot 2015; 47(1): 121-4.
[44]
Changizi-Ashtiyani S, Alizadeh M, Najafi H, et al. Physalis alkekengi and Alhagi maurorum ameliorate the side effect of cisplatin-induced nephrotoxicity. Cancer Gene Ther 2016; 23(7): 235-40.
[http://dx.doi.org/10.1038/cgt.2016.24] [PMID: 27255563]
[45]
Patel VK, Patel RV. Venkatakrishna-Bhatt H, Gopalakrishna G, Devasankariah G. A clinical appraisal of Anacyclus pyrethrum root extract in dental patients. Phytother Res 1992; 6(3): 158-9.
[http://dx.doi.org/10.1002/ptr.2650060313]
[46]
Manouze H, Bouchatta O, Gadhi AC, Bennis M, Sokar Z, Ba-M’hamed S. Anti-inflammatory, antinociceptive, and antioxidant activities of methanol and aqueous extracts of Anacyclus pyrethrum roots. Front Pharmacol 2017; 8(SEP): 598.
[http://dx.doi.org/10.3389/fphar.2017.00598] [PMID: 28928658]
[47]
Canli K, Yetgin A, Akata I, Altuner EM. Antimicrobial activity and chemical composition screening of Anacyclus pyrethrum root. Indian J Pharm Edu Res 2017; 51(3): S244-8.
[http://dx.doi.org/10.5530/ijper.51.3s.22]
[48]
Pirbalouti AG, Imaniyan-Fard M. Variation on biological activity and phytochemical characteristics of gum tragacanth exudate from Astragalus gossypinus and A. Parrowianus. Acta Sci Pol Hortorum Cultus 2016; 15(3): 141-52.
[49]
Paguigan ND, Castillo DHB, Chichioco-Hernandez CL. Anti-ulcer activity of leguminosae plants. Arq Gastroenterol 2014; 51(1): 64-7.
[http://dx.doi.org/10.1590/S0004-28032014000100013] [PMID: 24760067]
[50]
Khan ZI, Nahar B, Jakaria MA, Rahman S, Chowdhury MH, Rahmatullah M. An evaluation of antihyperglycemic and antinociceptive effects of methanol extract of cassia fistula l. (Fabaceae) leaves in Swiss albino mice. Adv Nat Applied Sci 2010; 4(3): 305-10.
[51]
Chaerunisaa AY, Milanda T, Susilawati Y. Activity of Cassia fistula L. Barks fractions as antibacterial agent. J Pharm Sci Res 2018; 10(2): 304-9.
[52]
Mane VD, Rajput PR, Malpani MO, Shirbhate MV. To study the effect of water extract of plant Cassia fistula as an antiinflammatory agent on Channa punctatus fish. Int J Chem Sci 2010; 10(1): 195-202.
[53]
Jangir R, Jain G. Evaluation of protective effects of hydroalcoholic extract of Cassia fistula Linn. Pod on pancreas in streptozotocin-induced diabetic rats. Pharmacognosy Res 2018; 10(2): 205-12.
[http://dx.doi.org/10.4103/pr.pr_95_17]
[54]
Suntar I, Kupeli Akkol E, Keles H, Yesilada E, Sarker SD, Baykal T. Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: stepwise isolation of an active component by in vivo bioassay and its mode of activity. J Ethnopharmacol 2012; 143(1): 299-309.
[http://dx.doi.org/10.1016/j.jep.2012.06.036] [PMID: 22750434]
[55]
Wesolowska A, Nikiforuk A, Michalska K, Kisiel W, Chojnacka-Wojcik E. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. J Ethnopharmacol 2006; 107(2): 254-8.
[http://dx.doi.org/10.1016/j.jep.2006.03.003] [PMID: 16621374]
[56]
Rahman H, Khan UA, Qasim M, et al. Ethnomedicinal Cichorium intybus seed extracts: An impending preparation against multidrug resistant bacterial pathogens. Jundishapur J Microbiol 2016; 9(11)e35436
[http://dx.doi.org/10.5812/jjm.35436] [PMID: 28138372]
[57]
Rezagholizadeh L, Pourfarjam Y, Nowrouzi A, et al. Effect of Cichorium intybus L. on the expression of hepatic NF-kB and IKKβ and serum TNF-α in STZ- and STZ+ niacinamide-induced diabetes in rats. Diabetol Metab Syndr 2016; 8(1): 11.
[http://dx.doi.org/10.1186/s13098-016-0128-6] [PMID: 26877773]
[58]
Brieudes V, Angelis A, Vougogiannopoulou K, et al. Phytochemical Analysis and Antioxidant Potential of the Phytonutrient-Rich Decoction of Cichorium spinosum and C. intybus. Planta Med 2016; 82(11-12): 1070-8.
[http://dx.doi.org/10.1055/s-0042-107472] [PMID: 27220071]
[59]
Zhou H, Ren J, Li Z. Antibacterial activity and mechanism of pinoresinol from Cinnamomum Camphora leaves against food-related bacteria. Food Control 2017; 79: 192-9.
[http://dx.doi.org/10.1016/j.foodcont.2017.03.041]
[60]
Li YR, Fu CS, Yang WJ, et al. Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Ethnopharmacol 2018; 221: 37-47.
[http://dx.doi.org/10.1016/j.jep.2018.04.017] [PMID: 29660467]
[61]
Zuo Z, Wang B, Ying B, Zhou L, Zhang R. Monoterpene emissions contribute to thermotolerance in Cinnamomum camphora. Trees (Berl) 2017; 31(6): 1759-71.
[http://dx.doi.org/10.1007/s00468-017-1582-y]
[62]
Bardaa S, Ben Halima N, Aloui F, et al. Oil from pumpkin (Cucurbita pepo L.) seeds: evaluation of its functional properties on wound healing in rats. Lipids Health Dis 2016; 15(1): 73.
[http://dx.doi.org/10.1186/s12944-016-0237-0] [PMID: 27068642]
[63]
Aljuraifani AA. Impact of solvent types on antimicrobial activities of pumpkin (Cucurbita pepo L.) pulp extracts. Asia Life Sci 2017; 26(2): 229-35.
[64]
Rotimi SO, Rotimi OA, Obembe OO. In silico analysis of compounds characterized from ethanolic extract of Cucurbita pepo with NF-kB-inhibitory potential. Bangladesh J Pharmacol 2014; 9(4): 551-6.
[http://dx.doi.org/10.3329/bjp.v9i4.20420]
[65]
Peiretti PG, Meineri G, Gai F, Longato E, Amarowicz R. Antioxidative activities and phenolic compounds of pumpkin (Cucurbita pepo) seeds and amaranth (Amaranthus caudatus) grain extracts. Nat Prod Res 2017; 31(18): 2178-82.
[http://dx.doi.org/10.1080/14786419.2017.1278597] [PMID: 28114838]
[66]
Sepehrimanesh M, Samimi N, Koohi-Hosseinabadi O, Mokhtari M, Amiri-Zadeh S, Farjam M. Effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat. J Coloproctol (Rio J) 2018; 38(4): 309-13.
[http://dx.doi.org/10.1016/j.jcol.2018.07.002]
[67]
Rguez S, Essid R, Adele P, et al. Towards the use of Cupressus sempervirens L. organic extracts as a source of antioxidant, antibacterial and antileishmanial biomolecules. Ind Crops Prod 2019; 131: 194-202.
[http://dx.doi.org/10.1016/j.indcrop.2019.01.056]
[68]
Hemmati AA, Kalantari H, Jalali A, Rezai S, Zadeh HH. Healing effect of quince seed mucilage on T-2 toxin-induced dermal toxicity in rabbit. Exp Toxicol Pathol 2012; 64(3): 181-6.
[http://dx.doi.org/10.1016/j.etp.2010.08.004] [PMID: 20832267]
[69]
Cerempei A, Muresan EI, Cimpoesu N, Carp-Carare C, Rimbu C. Dyeing and antibacterial properties of aqueous extracts from quince (Cydonia oblonga) leaves. Ind Crops Prod 2016; 94: 216-25.
[http://dx.doi.org/10.1016/j.indcrop.2016.08.018]
[70]
Kawahara T, Tsutsui K, Nakanishi E, Inoue T, Hamauzu Y. Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice. BMC Complement Altern Med 2017; 17(1): 80.
[http://dx.doi.org/10.1186/s12906-017-1606-6] [PMID: 28137259]
[71]
Bystricka J, Musilova J, Lichtnerova H, Lenkova M, Kovarovic J, Chalas M. The content of total polyphenols, ascorbic acid and antioxidant activity in selected varieties of quince (Cydonia oblonga Mill.) Potravinarstvo Slovak. J Food Sci 2017; 11(1): 77-81.
[http://dx.doi.org/10.5219/699]
[72]
Biradar S, Kangralkar VA, Mandavkar Y, Thakur M, Chougule N. Antiinflammatory, antiarthritic, analgesic and anticonvulsant activity of cyperus essential oils. Int J Pharm Pharm Sci 2010; 2(4): 112-5.
[73]
Seukep JA, Fankam AG, Djeussi DE, et al. Antibacterial activities of the methanol extracts of seven Cameroonian dietary plants against bacteria expressing MDR phenotypes. Springerplus 2013; 2(1): 363.
[http://dx.doi.org/10.1186/2193-1801-2-363] [PMID: 23961425]
[74]
Onuoha NO, Ogbusua NO, Okorie AN, Ejike CECC. Tigernut (Cyperus esculentus L.) “milk” as a potent “nutri-drink” for the prevention of acetaminophen-induced hepatotoxicity in a murine model. J Intercult Ethnopharmacol 2017; 6(3): 290-5.
[http://dx.doi.org/10.5455/jice.20170603094811] [PMID: 28894628]
[75]
Heidari MR, Azad EM, Mehrabani M. Evaluation of the analgesic effect of Echium amoenum Fisch & C.A. Mey. extract in mice: possible mechanism involved. J Ethnopharmacol 2006; 103(3): 345-9.
[http://dx.doi.org/10.1016/j.jep.2005.08.027] [PMID: 16185831]
[76]
Abolhassani M. Antibacterial effect of borage (Echium amoenum) on Staphylococcus aureus. Braz J Infect Dis 2004; 8(5): 382-5.
[77]
Abolhassani M. Antiviral activity of borage (Echium amoenum). Arch Med Sci 2010; 6(3): 366-9.
[http://dx.doi.org/10.5114/aoms.2010.14256] [PMID: 22371772]
[78]
Naseri N, Kalantar K, Amirghofran Z. Anti-inflammatory activity of Echium amoenum extract on macrophages mediated by inhibition of inflammatory mediators and cytokines expression. Res Pharm Sci 2018; 13(1): 73-81.
[http://dx.doi.org/10.4103/1735-5362.220970] [PMID: 29387114]
[79]
Bekhradnia S, Ebrahimzadeh MA. Antioxidant activity of Echium amoenum. Revista de Chimie 2016; 67(2): 223-6.
[80]
Bhanushali MM, Makhija DT, Joshi YM. Central nervous system activity of an aqueous acetonic extract of Ficus carica L. in mice. J Ayurveda Integr Med 2014; 5(2): 89-96.
[http://dx.doi.org/10.4103/0975-9476.131734] [PMID: 24948859]
[81]
Debib A, Tir-Touil MA, Meddah B, Hamaidi-Chergui F, Menadi S, Alsayadi MS. Evaluation of antimicrobial and antioxidant activities of oily macerates of Algerian dried figs (Ficus carica L.). Int Food Res J 2018; 25(1): 351-6.
[82]
Sharma SH, Kumar JS, Chellappan DR, Nagarajan S. Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomed Pharmacother 2018; 100: 367-73.
[http://dx.doi.org/10.1016/j.biopha.2018.02.035] [PMID: 29453046]
[83]
Keskin I, Gunal Y, Ayla S, et al. Effects of Foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing. Biotech Histochem 2017; 92(4): 274-82.
[http://dx.doi.org/10.1080/10520295.2017.1306882] [PMID: 28426256]
[84]
Momenzadeh F, Toghiri MA, Taghizadeh M, Mahlioji M, Rafiee F. Comparison the effect of fennel and mefenamic acid on severity of primary dysmenorrhea. Majallah-i Zanan, Mamai va Nazai-i Iran 2017; 20(4): 44-9.
[85]
Mahdavi S, Alizad M, Sajjadi P, Baleghi M. A study of the antioxidant and antimicrobial effects of ethanolic extract of fennel (Foeniculum vulgare mill) seeds. Majallah-i Danishgah-i Ulum-i Pizishki-i Babul 2017; 19(5): 32-8.
[86]
Rezayat SM, Dehpour AR, Motamed SM, et al. Foeniculum vulgare essential oil ameliorates acetic acid-induced colitis in rats through the inhibition of NF-kB pathway. Inflammopharmacology 2017; 1-9.
[PMID: 29067571]
[87]
Agarwal D, Saxena SN, Sharma LK, Lal G. Prevalence of essential and fatty oil constituents in fennel (Foeniculum vulgare Mill) genotypes grown in semi-arid regions of India. J Essential Oil-Bearing Plant 2018; 21(1): 40-51.
[http://dx.doi.org/10.1080/0972060X.2018.1433072]
[88]
Samareh FM, Poursalehi HR, Mandegary A, et al. The effect of methanol extract of fennel on bleomycin-induced pulmonary fibrosis in rats 2015.
[89]
Yang Y, Wang S, Bao YR, et al. Anti-ulcer effect and potential mechanism of licoflavone by regulating inflammation mediators and amino acid metabolism. J Ethnopharmacol 2017; 199: 175-82.
[http://dx.doi.org/10.1016/j.jep.2017.01.053] [PMID: 28159726]
[90]
Shi Y, Wu D, Sun Z, et al. Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. Phytother Res 2012; 26(9): 1410-7.
[http://dx.doi.org/10.1002/ptr.3715] [PMID: 22389128]
[91]
Aluckal E, Ismail A, Paulose A, et al. Assessment of total antioxidant capacity and antimicrobial activity of Glycyrrhiza glabra in saliva of HIV-infected patients. J Pharm Bioallied Sci 2017; 9(5)(Suppl. 1): S237-40.
[http://dx.doi.org/10.4103/jpbs.JPBS_141_17] [PMID: 29284971]
[92]
Samareh Fekri M, Poursalehi HR, Sharififar F, Mandegary A, Rostamzadeh F, Mahmoodi R. The effects of methanolic extract of Glycyrrhiza glabra on the prevention and treatment of bleomycin-induced pulmonary fibrosis in rat: experimental study. Drug Chem Toxicol 2019; 1-7.
[http://dx.doi.org/10.1080/01480545.2019.1606232] [PMID: 31072167]
[93]
Velvizhi S, Annapurani S. Estimation of total flavonoid, phenolic content, and free radical scavenging potential of Glycyrrhiza glabra root extract. Asian J Pharm Clin Res 2018; 11(4): 231-5.
[http://dx.doi.org/10.22159/ajpcr.2018.v11i4.23711]
[94]
Ismail H, Mirza B. Evaluation of analgesic, anti-inflammatory, anti-depressant and anti-coagulant properties of Lactuca sativa (CV. Grand Rapids) plant tissues and cell suspension in rats. BMC Complement Altern Med 2015; 15(1): 199.
[http://dx.doi.org/10.1186/s12906-015-0742-0] [PMID: 26115918]
[95]
Bhat RS, Al-Daihan S. Phytochemical constituents and antibacterial activity of some green leafy vegetables. Asian Pac J Trop Biomed 2014; 4(3): 189-93.
[http://dx.doi.org/10.1016/S2221-1691(14)60230-6] [PMID: 25182436]
[96]
Adesso S, Pepe G, Sommella E, et al. Anti-inflammatory and antioxidant activity of polyphenolic extracts from Lactuca sativa (var. Maravilla de Verano) under different farming methods. J Sci Food Agric 2016; 96(12): 4194-206.
[http://dx.doi.org/10.1002/jsfa.7622] [PMID: 26777118]
[97]
Kim HD, Hong KB, Noh DO, Suh HJ. Sleep-inducing effect of lettuce (Lactuca sativa) varieties on pentobarbital-induced sleep. Food Sci Biotechnol 2017; 26(3): 807-14.
[http://dx.doi.org/10.1007/s10068-017-0107-1] [PMID: 30263607]
[98]
Arzi A, Karampour NS, Khorasgani ZN, Dashtizadeh A. Study of the analgesic effect of hydro-alcoholic extract of red lentil in rat by formalin test. Res J Pharm Biol Chem Sci 2015; 6(3): 39-46.
[99]
Shenkarev ZO, Melnikova DN, Finkina EI, et al. Ligand Binding Properties of the Lentil Lipid Transfer Protein: Molecular Insight into the Possible Mechanism of Lipid Uptake. Biochemistry 2017; 56(12): 1785-96.
[http://dx.doi.org/10.1021/acs.biochem.6b01079] [PMID: 28266846]
[100]
Chkhikvishvili I, Mamniashvili T, Gogia N, Enukidze M, Machavariani M, Sanikidze T. Antioxidant, anti-inflammatory activity of georgian leguminous crops cultures. Georgian Med News 2017; (272): 147-53.
[PMID: 29227275]
[101]
Rafiee S, Nekouyian N, Hosseini S, et al. Effect of topical linum usitatissimum on full thickness excisional skin wounds. Trauma Mon 2017; 22(6)
[http://dx.doi.org/10.5812/traumamon.39045]
[102]
Setayesh M, Sadeghifar AR, Nakhaee N, Kamalinejad M, Rezaeizadeh H. A topical gel from flax seed oil compared with hand splint in carpal tunnel syndrome: a randomized clinical trial. J Evid Based Complementary Altern Med 2017; 22(3): 462-7.
[http://dx.doi.org/10.1177/2156587216677822] [PMID: 27909031]
[103]
Rafieian-Kopaei M, Shakiba A, Sedighi M, Bahmani M. The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c mice. J Evid Based Complementary Altern Med 2017; 22(4): 892-6.
[http://dx.doi.org/10.1177/2156587217717416] [PMID: 28750553]
[104]
Yousaf S, Ilyas M, Khattak AK, Satti SZ, Jan I. Antimicrobial activities and mineral profile of selected wild plant Linum usitatissimum in Khyber Pakhtunkhwa, Pakistan. Soil Environ 2017; 36(1): 45-50.
[http://dx.doi.org/10.25252/SE/17/41156]
[105]
Han H, Yilmaz H, Gulcin I. Antioxidant activity of flaxseed (Linum usitatissimum L.) shell and analysis of its polyphenol contents by LC-MS/MS. Rec Nat Prod 2018; 12(4): 397-402.
[http://dx.doi.org/10.25135/rnp.46.17.09.155]
[106]
Afshar M, Ravarian B, Zardast M, Moallem SA, Fard MH, Valavi M. Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in BALB/c mice. Iran J Basic Med Sci 2015; 18(6): 616-22.
[PMID: 26221487]
[107]
Esteves PF, Sato A, Esquibel MA, de Campos-Buzzi F, Meira AV, Cechinel-Filho V. Antinociceptive activity of Malva sylvestris L. Lat Am J Pharm 2009; 28(3): 454-6.
[108]
Alizadeh F, Khodavandi A, Faraji FS. Malva sylvestris inhibits Candida albicans biofilm formation. J HerbMed Pharmacol 2017; 6(2): 62-8.
[109]
Azadpour M, Azadpour N, Bahmani M, Hassanzadazar H, Rafieian-Kopaei M, Naghdi N. Antimicrobial effect of Ginger (Zingiber officinale) and mallow (Malva sylvestris) hydroalcholic extracts on four pathogen bacteria. Der Pharmacia Lett 2016; 8(1): 181-7.
[110]
Martins CAF, Campos ML, Irioda AC, Stremel DP, Trindade ACLB, Pontarolo R. Anti-inflammatory effect of malva sylvestris,sida cordifolia, and pelargonium graveolens is related to inhibition of prostanoid production. Molecules 2017; 22(11)E1883
[http://dx.doi.org/10.3390/molecules22111883] [PMID: 29099738]
[111]
Saad AB, Rjeibi I, Alimi H, et al. Lithium induced, oxidative stress and related damages in testes and heart in male rats: The protective effects of Malva sylvestris extract. Biomed Pharmacother 2017; 86: 127-35.
[http://dx.doi.org/10.1016/j.biopha.2016.12.004] [PMID: 27951419]
[112]
Gul H, Abbas K, Qadir MI. Gastro-protective effect of ethanolic extract of mentha longifolia in alcohol- and aspirin-induced gastric ulcer models. Bangladesh J Pharmacol 2015; 10(1): 241-5.
[http://dx.doi.org/10.3329/bjp.v10i1.21689]
[113]
Amabeoku GJ, Erasmus SJ, Ojewole JAO, Mukinda JT. Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice. Methods Find Exp Clin Pharmacol 2009; 31(10): 645-9.
[http://dx.doi.org/10.1358/mf.2009.31.10.1441861] [PMID: 20140273]
[114]
Shahbazi Y. Antibacterial and antioxidant properties of methanolic extracts of some native edible plants collected from Kermanshah. Western Iran J Food Quality Hazards Cont 2017; 4(4): 93-8.
[115]
Ibrahim SRM, Abdallah HM, Elkhayat ES, et al. Fusaripeptide A: new antifungal and anti-malarial cyclodepsipeptide from the endophytic fungus Fusarium sp. J Asian Nat Prod Res 2018; 20(1): 75-85.
[http://dx.doi.org/10.1080/10286020.2017.1320989] [PMID: 28446036]
[116]
Ibrahim AY, Youness ER, Shalaby AS, El-Din MM. Anti-acetylcholinesterase, anti-inflammatory and anti-oxidant activities of mentha longifolia for treating alzheimer disease. Der Pharmacia Lettre 2016; 8(7): 34-9.
[117]
Nesello LAN, Beleza MLML, Mariot M, et al. Gastroprotective value of berries: evidences from methanolic extracts of morus nigra and rubus niveus fruits. Gastroenterol Res Practice 2017; 2017
[118]
Chen H, Yu W, Chen G, Meng S, Xiang Z, He N. Antinociceptive and antibacterial properties of anthocyanins and flavonols from fruits of black and non-black mulberries. Molecules 2017; 23(1)E4
[http://dx.doi.org/10.3390/molecules23010004] [PMID: 29267231]
[119]
Aulifa DL, Fitriansyah SN, Ardiansyah SA, Wibowo DP, Julata YA, Christy DS. Phytochemical screening, antibacterial activity, and mode of action on morus nigra. Pharmacogn J 2018; 10(1): 167-71.
[http://dx.doi.org/10.5530/pj.2018.1.28]
[120]
Montenote MC, Wajsman VZ, Konno YT, et al. Antioxidant effect of morus nigra on chagas disease progression. Rev Inst Med Trop Sao Paulo 2017.59e73
[http://dx.doi.org/10.1590/s1678-9946201759073] [PMID: 29116293]
[121]
Li Y, Bao T, Chen W. Comparison of the protective effect of black and white mulberry against ethyl carbamate-induced cytotoxicity and oxidative damage. Food Chem 2018; 243: 65-73.
[http://dx.doi.org/10.1016/j.foodchem.2017.09.106] [PMID: 29146371]
[122]
Banylla SN, Rita S, Subhalakshmi Devi A, Dharmaraja Meetei U, Sania Monica KH, Pfuzia A. Anti-ulcer activity of the aqueous extract of Portulaca Racea L. In aspirin plus pyloric ligation induced ulcer in albino rats. Int J Pharma Bio Sci 2013; 4(2): 576-P80.
[123]
Keshavarzi K, Moradi M, Khoshnam SE, et al. Evaluation the effect of hydro-alcoholic extract of portulaca oleracea and estradiol on pain threshold in female mice. Faslnamah-i Giyahan-i Daruyi 2017; 16(62): 29-37.
[124]
Du YK, Liu J, Li XM, et al. Flavonoids extract from Portulaca oleracea L. induce Staphylococcus aureus death by apoptosis-like pathway. Int J Food Prop 2017; 20: S534-42.
[http://dx.doi.org/10.1080/10942912.2017.1300812]
[125]
Kim DG, Shin JH, Kang MJ. Antioxidant and anti-inflammatory activities of water extracts and ethanol extracts from Portulaca oleracea L. Korean J Food Preserv 2018; 25(1): 98-106.
[126]
Mishra N, Gill NS, Mishra A, Mishra S, Shukla A, Upadhayay A. Evaluation of antioxidant and antiulcer potentials of prunus domestica fruit methanolic and extract on wistar albino rats. J Pharmacol Toxicol 2012; 7(6): 305-11.
[http://dx.doi.org/10.3923/jpt.2012.305.311]
[127]
Yaqeen Z, Naqvi NH, Imran H, et al. Evaluation of analgesic activity of P. domestica L. Pak J Pharm Sci 2013; 26(1): 91-4.
[PMID: 23261732]
[128]
El-Beltagi HS, El-Ansary AE, Mostafa MA, Kamel TA, Safwat G. Evaluation of the phytochemical, antioxidant, antibacterial and anticancer activity of Prunus domestica fruit. Not Bot Horti Agrobot Cluj-Napoca 2019; 47(2): 395-404.
[http://dx.doi.org/10.15835/nbha47111402]
[129]
Hooshmand S, Kumar A, Zhang JY, Johnson SA, Chai SC, Arjmandi BH. Evidence for anti-inflammatory and antioxidative properties of dried plum polyphenols in macrophage RAW 264.7 cells. Food Funct 2015; 6(5): 1719-25.
[http://dx.doi.org/10.1039/C5FO00173K] [PMID: 25921826]
[130]
Nasiri E, Hosseinimehr SJ, Akbari J, Azadbakht M, Azizi S. The effects of punica granatum flower extract on skin injuries induced by burn in rats. Adv Pharmacol Sci 2017; 2017
[131]
Nadia Z, Aicha M, Sihem H, Abdelmalik B. In vivo analgesic activities and safety assessment of vitis vinifera L and punica granatum L fruits extracts. Trop J Pharm Res 2017; 16(3): 553-61.
[http://dx.doi.org/10.4314/tjpr.v16i3.8]
[132]
Mohamed Z, Ridha OM, Eddine LS, Rebiai A. Phenolic content, antioxidant and antibacterial activities of peel extract from punica granatum L. Res J Chem Environ 2018; 22(4): 9-15.
[133]
Xu J, Zhao Y, Aisa HA. Anti-inflammatory effect of pomegranate flower in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Pharm Biol 2017; 55(1): 2095-101.
[http://dx.doi.org/10.1080/13880209.2017.1357737] [PMID: 28832232]
[134]
Mohammadi S, Zarei M, Zarei MM, Salehi I. Effect of hydroalcoholic leaves extract of Rhus coriaria on pain in male rats. Anesth Pain Med 2016; 6(1)e32128
[http://dx.doi.org/10.5812/aapm.32128] [PMID: 27047792]
[135]
Rashid TS, Awla HK, Sijam K. Antifungal effects of Rhus coriaria L. fruit extracts against tomato anthracnose caused by Colletotrichum acutatum. Ind Crops Prod 2018; 113: 391-7.
[http://dx.doi.org/10.1016/j.indcrop.2018.01.066]
[136]
El Hasasna H, Saleh A, Al Samri H, et al. Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFkB and nitric oxide pathways. Sci Rep 2016; 6: 21144.
[http://dx.doi.org/10.1038/srep21144] [PMID: 26888313]
[137]
Najjar F, Rizk F, Carnac G, et al. Protective effect of Rhus coriaria fruit extracts against hydrogen peroxide-induced oxidative stress in muscle progenitors and zebrafish embryos. PeerJ 2017; 5(12)e4144
[http://dx.doi.org/10.7717/peerj.4144] [PMID: 29250470]
[138]
Kim YW, Baek SR, Lee ES, et al. Wound healing effects of rose placenta in a mouse model of full-thickness wounds. Arch Plast Surg 2015; 42(6): 686-94.
[http://dx.doi.org/10.5999/aps.2015.42.6.686] [PMID: 26618114]
[139]
Niazi M, Hashempur MH, Taghizadeh M, Heydari M, Shariat A. Efficacy of topical Rose (Rosa damascena Mill.) oil for migraine headache: A randomized double-blinded placebo-controlled cross-over trial. Complement Ther Med 2017; 34: 35-41.
[http://dx.doi.org/10.1016/j.ctim.2017.07.009] [PMID: 28917373]
[140]
Li J, Kong WS, Liu X, et al. A new isoflavone derivative from Rosa Damascena and its antibacterial activity. Zhongguo Zhongyao Zazhi 2018; 43(2): 332-5.
[PMID: 29552852]
[141]
Khare S, Gupta M, Cheema HS, et al. Rosa damascena restrains Plasmodium falciparum progression in vitro and impedes malaria pathogenesis in murine model. Biomed Pharmacother 2018; 97: 1654-62.
[http://dx.doi.org/10.1016/j.biopha.2017.11.130] [PMID: 29793328]
[142]
Zahedi-Amiri Z, Taravati A, Hejazian LB. Protective effect of rosa damascena against aluminum chloride-induced oxidative stress. Biol Trace Elem Res 2018; 1-8.
[PMID: 29704206]
[143]
Ahmed N, Ali Khan MS, Mat Jais AM, et al. Anti-ulcer activity of sandalwood (Santalum album L.) stem hydro-alcoholic extract in three gastric-ulceration models of wistar rats. Bol Latinoam Caribe Plantas Med Aromat 2013; 12(1): 81-91.
[144]
Okugawa H, Ueda R, Matsumoto K, Kawanishi K, Kato A. Effect of α-santalol and β-santalol from sandalwood on the central nervous system in mice. Phytomedicine 1995; 2(2): 119-26.
[http://dx.doi.org/10.1016/S0944-7113(11)80056-5] [PMID: 23196153]
[145]
Sreedevi R, Damodharam T. Phytochemical and antibacterial activities of Santalum album. Int J Pharm Sci Rev Res 2015; 33(1): 280-3.
[146]
Liu W, Chen S, Li J, Yang X, Yan C, Liu H. A new β-tetralonyl glucoside from the Santalum album derived endophytic fungus Colletotrichum sp. GDMU-1. Nat Prod Res 2018; 1-6.
[PMID: 29553810]
[147]
Kamal R, Yadav S, Mathur M, Katariya P. Antiradical efficiency of 20 selected medicinal plants. Nat Prod Res 2012; 26(11): 1054-62.
[http://dx.doi.org/10.1080/14786419.2011.553720] [PMID: 22010999]
[148]
El-Meligy RM, Awaad AS, Soliman GA, Kenawy SA, Alqasoumi SI. Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants. Saudi Pharm J 2017; 25(3): 387-96.
[http://dx.doi.org/10.1016/j.jsps.2016.10.008] [PMID: 28344494]
[149]
Aflatoonian MR, Pilevarzadeh M, Dastyar N. The effect of solanum nigrum plant on muscle soreness. Res J Pharm Biol Chem Sci 2016; 7(5): 1385-9.
[150]
Khan S, Shinwari MI, Haq A, et al. Fourier-transform infrared spectroscopy analysis and antifungal activity of methanolic extracts of Medicago parviflora, Solanum Nigrum, Melilotus alba and Melilotus indicus on soil-borne phytopathogenic fungi. Pak J Bot 2018; 50(4): 1591-8.
[151]
Xiang L, Wang Y, Yi X, He X. Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L. (European black nightshade). Phytochemistry 2018; 148: 87-96.
[http://dx.doi.org/10.1016/j.phytochem.2018.01.019] [PMID: 29421515]
[152]
Hameed A, Akhtar N. Comparative chemical investigation and evaluation of antioxidant and tyrosinase inhibitory effects of Withania somnifera (L.) Dunal and Solanum nigrum (L.) berries. Acta Pharm 2018; 68(1): 47-60.
[http://dx.doi.org/10.2478/acph-2018-0007] [PMID: 29453917]
[153]
Gupta S, Singh A. Antimicrobial, analgesic and anti - inflammatory activity reported on tamarindus indica Linn Root extract. Pharmacogn J 2017; 9(3): 410-6.
[http://dx.doi.org/10.5530/pj.2017.3.70]
[154]
Kumar D, Sanghi A, Arora S, Chandra R, Thakur N. Individual and combined effects of extracts of leaves and bark of Tamarindus indica on invitro membrane stabilizing and antioxidant activities. J Pharm Sci Res 2017; 9(1): 44-8.
[155]
Patel A, Biswas S, Shoja MH, Ramalingayya GV, Nandakumar K. Protective effects of aqueous extract of Solanum nigrum Linn. leaves in rat models of oral mucositis. Sci World J 2014.2014345939
[http://dx.doi.org/10.1155/2014/345939] [PMID: 25506066]
[156]
Thotambailu AM, Bhandary BSK, Sharmila KP. Protective effect of punica granatum extract in head and neck cancer patients undergoing radiotherapy. Indian J Otolaryngol Head Neck Surg 2018; 1-3.
[PMID: 31741979]
[157]
Demir Dogan M, Can G, Meral R. Effectiveness of black mulberry molasses in prevention of radiotherapy-induced oral mucositis: a randomized controlled study in head and neck cancer patients. J Altern Complement Med 2017; 23(12): 971-9.
[http://dx.doi.org/10.1089/acm.2016.0425] [PMID: 28677999]
[158]
Rezaeipour N, Jafari F, Rezaeizadeh H, et al. Efficacy of a Persian medicine herbal compound (Alcea digitata Alef and Malva sylvestris L.) on prevention of radiation induced acute mucositis in patients with head and neck cancer: A pilot study. Int J Cancer Management 2017; 10(9)
[http://dx.doi.org/10.5812/ijcm.8642]
[159]
Panahi Y, Saadat A, Shadboorestan A, Ahmadi A. An updated review of natural products intended to prevent or treat oral mucositis in patients undergoing radio-chemotherapy. Curr Pharm Biotechnol 2016; 17(11): 949-61.
[http://dx.doi.org/10.2174/1389201017666160808094008] [PMID: 27640644]
[160]
Das D, Agarwal SK, Chandola HM. Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies. Ayu 2011; 32(2): 196-9.
[http://dx.doi.org/10.4103/0974-8520.92579] [PMID: 22408302]