Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

Renato       Cozzi; Maria    R.   Ambrosio; Roberto       Attanasio; Alessandro       Bozzao; Laura       De Marinis; Ernesto       De Menis; Edoardo       Guastamacchia; Andrea       Lania; Giovanni       Lasio; Francesco       Logoluso; Pietro       Maffei; Maurizio       Poggi; Vincenzo       Toscano; Michele       Zini; Philippe       Chanson; Laurence       Katznelson
Abstract

Acromegaly is a rare disease. Improvements in lifespan in these patients have recently been reported due to transsphenoidal surgery (TSS), advances in medical therapy, and strict criteria for defining disease remission. This document reports the opinions of a group of Italian experts who have gathered together their prolonged clinical experience in the diagnostic and therapeutic challenges of acromegaly patients. Both GH and IGF-I (only IGF-I in those treated with Pegvisomant) are needed in the diagnosis and follow-up. Comorbidities (cardio-cerebrovascular disease, sleep apnea, metabolic derangement, neoplasms, and bone/joint disease) should be specifically addressed. Any newly diagnosed patient should be referred to a multidisciplinary team experienced in the treatment of pituitary adenomas.
Keywords: Acromegaly, pituitary, comorbidities, discrepant, GH, IGF-I.
Graphical Abstract

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Cite As
Endocrine, Metabolic & Immune Disorders - Drug Targets

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

Abstract

Graphical Abstract
