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Current Neuropharmacology

Author(s): Huidan Weng, Yihong Ma, Lina Chen, Guoen Cai, Zhiting Chen, Shaochuan Zhang* and Qinyong Ye*

DOI: 10.2174/1570159X18666200123165002

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A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family

Page: [613 - 623] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Mitochondrial damage is involved in many pathophysiological processes, such as tumor development, metabolism, and neurodegenerative diseases. The mitochondrial unfolded protein response (mtUPR) is the first stress-protective response initiated by mitochondrial damage, and it repairs or clears misfolded proteins to alleviate this damage. Studies have confirmed that the sirtuin family is essential for the mitochondrial stress response; in particular, SIRT1, SIRT3, and SIRT7 participate in the mtUPR in different axes. This article summarizes the associations of sirtuins with the mtUPR as well as specific molecular targets related to the mtUPR in different disease models, which will provide new inspiration for studies on mitochondrial stress, mitochondrial function protection, and mitochondria-related diseases, such as neurodegenerative diseases.

Keywords: SIRT, mitochondrial unfolded protein response, mitochondrial stress, AMPK, FOXO3A, CHOP, PARP, mitochondrial protein quality control.

Graphical Abstract

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