Abstract
Tuberculosis (TB) is one such disease that has become a nuisance in the world scenario and
one of the most deadly diseases of the current times. The etiological agent of tuberculosis, Mycobacterium
tuberculosis (M. tb) kills millions of people each year. Not only 1.7 million people worldwide are
estimated to harbor M. tb in the latent form but also 5 to 15 percent of which are expected to acquire an
infection during a lifetime. Though curable, a long duration of drug regimen and expense leads to low
patient adherence. The emergence of multi-, extensive- and total- drug-resistant strains of M. tb further
complicates the situation. Owing to high TB burden, scientists worldwide are trying to design novel
therapeutics to combat this disease. Therefore, to identify new drug targets, there is a growing interest in
targeting DNA repair pathways to fight this infection. Thus, this review aims to explore DNA repair and
damage tolerance as an efficient target for drug development by understanding M. tb DNA repair and
tolerance machinery and its regulation, its role in pathogenesis and survival, mutagenesis, and consequently,
in the development of drug resistance.
Keywords:
DNA repair, Tuberculosis, Drug resistance, Damage tolerance, Drug targets, Pathogenesis, Mutation rate.
Graphical Abstract
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