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Letters in Organic Chemistry

Author(s): Yi Cheng, Runmei Zhang, Tianhao Lu, Yong Shen, Min Wang and Chunsong Xie*

DOI: 10.2174/1570178617666191218104959

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Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes

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Abstract

Under mild conditions, C3-quaternary 2H-pyrrolines can be convergently and efficiently assembled by Cu(II) and weak bases cocatalyzed [3+2] cycloaddition of 1,1-disubstituted alkenes and isocyanoacetates. Various functionalities can be tolerated, affording 2H-pyrrolines with up to two quaternary centers in a single step.

Keywords: 2H-pyrroline, copper catalysis, isocyanoacetate, isonitrile, cycloaddition, quaternary carbon.

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