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Current Topics in Medicinal Chemistry

Author(s): Deyani Nocedo-Mena, Elvira Garza-González, Mauricio González-Ferrara and María del Rayo Camacho-Corona*

DOI: 10.2174/1568026619666191121123926

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Antibacterial Activity of Cissus incisa Extracts against Multidrug- Resistant Bacteria

Page: [318 - 323] Pages: 6

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Abstract

Aims: The need to find new antimicrobial agents to cope with this phenomenon increases.

Background: Infection diseases are illness caused by different microorganisms, such as bacteria, among those caused by resistant bacteria are associated with greater morbidity, mortality and cost of the treatment than those caused by sensitive bacteria of the same species.

Objective: Need to find new antimicrobial agents to cope with this phenomenon increases.

Methods: This work carried out the study of biological activities of Cissus incisa, taking account its traditional use. Three extracts were prepared from the leaves of this plant: hexane, chloroform methanol (1:1) and aqueous. Their antibacterial and antitubercular activities were evaluated using microdilution and alamar blue assays; respectively.

Results: The chloroform/methanol extract (1:1) was the most active of the three tested extracts for antimicrobial activity. In this way, the extract exhibits a broad spectrum of antimicrobial activity, against the Gram positive and Gram negative bacteria tested, with MIC values between 125 to 500 μg/mL.

Conclusion: This research contributes both to the knowledge of the Mexican flora, as well as the discovery of potential antibacterial agents derivate from plants.

Keywords: Cissus incisa, Antibacterial resistance, Natural products, Tuberculosis, Multidrug-resistant bacteria, Viral infections.

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