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Current Drug Discovery Technologies

Author(s): Goutam Chandra*, Devaleena Mukherjee, Anushree Singha Ray, Soroj Chatterjee and Indranil Bhattacharjee

DOI: 10.2174/1570163816666191106103730

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Phytoextracts as Antibacterials: A Review

Page: [523 - 533] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Botanicals have been cultured to flavour food, to treat health disorders and to put a stop to diseases caused by various microorganisms. The awareness of curative features of different medicinal plants has been spread among human communities. The application of herbal products as antimicrobial agents may be a better choice for the extensive and imprudent use of synthetic antibiotics. World Health Organization recommended traditional medicines as the safest remedies for the treatment of diseases of microbial origin. The plant extracts are generally nonhazardous, available in plenty at reasonable prices, biodegradable, eco-friendly and sometimes show broad-spectrum activities against different microorganisms. The current knowledge on plant extracts, phytochemicals and their antibacterial activity, target specific mechanism of action, solvents deployed during extraction, properties of an active ingredient isolated may help in biological control of bacteria. Antimicrobial properties of different plant parts, which act in a low dose, have been organised separately for easy understanding.

Keywords: Different plant parts, phytochemicals, antibacterial activity, active ingredients, phytoextracts, bioactive compounds.

Graphical Abstract

[1]
Cronquist A. The Evolution and Classification of Flowering Plants New York Botanical Garden, Bronx 1988.
[2]
Tippo O, Stern WL. Humanistic Botany. W W Norton pub 1977.
[3]
Verpoorte R. Pharmacognosy in the new millennium: leadfinding and biotechnology. J Pharm Pharmacol 2000; 52(3): 253-62.
[http://dx.doi.org/10.1211/0022357001773931] [PMID: 10757412]
[4]
Bhattacharjee I, Chatterjee SK, Chatterjee S, Chandra G. Antibacterial potentiality of Argemone mexicana solvent extracts against some pathogenic bacteria. Mem Inst Oswaldo Cruz 2006; 101(6): 645-8.
[http://dx.doi.org/10.1590/S0074-02762006000600011] [PMID: 17072477]
[5]
Bhattacharjee I, Chatterjee SK, Ghosh A, Chandra G. Antibacterial activities of some plant extracts used in Indian traditional folk medicine. Asian Pac J Trop Biomed 2011; 1(2): S165-9.
[http://dx.doi.org/10.1016/S2221-1691(11)60148-2]
[6]
Alma MH, Mavi A, Yildirim A, Digrak M, Hirata T. Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey. Biol Pharm Bull 2003; 26(12): 1725-9.
[http://dx.doi.org/10.1248/bpb.26.1725] [PMID: 14646179]
[7]
Bhattacharjee I, Ghosh A, Chandra G. Antimicrobial activity of the essential oil of Cestrum diurnum (L.) (Solanales: Solanaceae). Afr J Biotechnol 2005; 4(4): 371-4.
[8]
Klausmeyer P, Chmurny GN, McCloud TG, Tucker KD, Shoemaker RH. A novel antimicrobial indolizinium alkaloid from Aniba panurensis. J Nat Prod 2004; 67(10): 1732-5.
[http://dx.doi.org/10.1021/np040114e] [PMID: 15497951]
[9]
Carlson HJ, Bissell HD, Muller MG. Antimalarial and antibacterial substances separated from higher plants. J Bacteriol 1946; 52: 155-68.
[http://dx.doi.org/10.1128/JB.52.2.155-168.1946]
[10]
Lucas EH, Pearson K, et al. Preparation of crude plant extracts and their assay for presence of antibacterial substances. Food Res 1948; 13(1): 82-8.
[http://dx.doi.org/10.1111/j.1365-2621.1948.tb16597.x] [PMID: 18902490]
[11]
Gottshall RY, Lucas EH, Ardith L, Roberts JM. The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 1949; 28: 920.
[http://dx.doi.org/10.1172/JCI102179]
[12]
Kamat VN, Desa J, Vaz A, Fernandes F, Bhatnagar SS. Isolation and characterization of chemical constituents from Vinca rosea Linn (N.O. Apocynaceae). Indian J Med Res 1958; 46(4): 588-97.
[PMID: 13574849]
[13]
Sokomba E, Wambebe C, Chowdhury BK, Iriah J, Ogbeide ON, Orkor D. Preliminary phytochemical, pharmacological and antibacterial studies of the alkaloidal extracts of the leaves of Synclisia scabrida Miers. J Ethnopharmacol 1986; 18(2): 173-85.
[http://dx.doi.org/10.1016/0378-8741(86)90029-2] [PMID: 3104690]
[14]
Odelola HA, Okorosobo VI. Preliminary investigation of in-vitro antimicrobial activity of two Nigerian Diospyros species (Ebenaceae). Afr J Med Med Sci 1988; 17(3): 167-70.
[PMID: 2845757]
[15]
Toda M, Okubo S, Ohnishi R, Shimamura T. Antibacterial and bactericidal activities of Japanese green tea Nippon Saikingaku Zasshi 1989; 44(4): 669-72.
[http://dx.doi.org/10.3412/jsb.44.669] [PMID: 2677434]
[16]
Yam TS, Shah S, Hamilton-Miller JM. Microbiological activity of whole and fractionated crude extracts of tea (Camellia sinensis), and of tea components. FEMS Microbiol Lett 1997; 152(1): 169-74.
[http://dx.doi.org/10.1111/j.1574-6968.1997.tb10424.x] [PMID: 9228784]
[17]
Al-mughrabi K. Antimicrobial activity of extracts from leaves stems and flowers of Euphorbia macroclada against plant pathogenic fungi. Phytopathol Mediterr 2003; 42: 245-50.
[18]
Zaidan MR, Noor Rain A, Badrul AR, Adlin A, Norazah A, Zakiah I. In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. Trop Biomed 2005; 22(2): 165-70.
[PMID: 16883283]
[19]
Oliveira DF, Pereira AC, Figueiredo HC, et al. Antibacterial activity of plant extracts from Brazilian southeast region. Fitoterapia 2007; 78(2): 142-5.
[http://dx.doi.org/10.1016/j.fitote.2006.09.027] [PMID: 17169500]
[20]
Karmegam N, Karuppusamy S, Prakash M, Jayakumar M, Rajasekar K. Antibacterial potency and synergistic effect of certain plant extracts against food-borne diarrheagenic bacteria. Int J Biomed Pharm Sci 2008; 2: 88-93.
[21]
Parekh J, Chanda SV. Antibacterial activity of aqueous and alcoholic extracts of 34 Indian medicinal plants against some Staphylococcus species. Turk J Biol 2008; 32: 63-71.
[22]
Gowri1 SS, Vasantha K. Phytochemical screening and antibacterial activity of Syzygium cumini (L.) (Myrtaceae) leaves extracts. Int J Pharm Tech Res 2010; 2: 1569-73.
[23]
Panghal M, Kaushal V, Yadav JP. In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases. Ann Clin Microbiol Antimicrob 2011; 10: 21.
[http://dx.doi.org/10.1186/1476-0711-10-21] [PMID: 21599889]
[24]
Bibi Y, Nisa S, Chaudhary FM, Zia M. Antibacterial activity of some selected medicinal plants of Pakistan. BMC Complement Altern Med 2011; 11: 52.
[http://dx.doi.org/10.1186/1472-6882-11-52] [PMID: 21718504]
[25]
Chandra M. Antimicrobial Activity of Medicinal Plants against Human Pathogenic Bacteria. Int J Biotechnol Bioengineering Res 2013; 4: 653-8.
[26]
Seukep JA, Fankam AG, Djeussi DE, et al. Antibacterial activities of the methanol extracts of seven Cameroonian dietary plants against bacteria expressing MDR phenotypes. Springerplus 2013; 2: 363.
[http://dx.doi.org/10.1186/2193-1801-2-363] [PMID: 23961425]
[27]
Dhanalakshmi D, Manimegalai K. Antibacterial activity of leaf and seed extracts of Delonix regia and Achyranthus aspera against selected bacterial strains Int J Pharm Med Bio Sc 2013.
[28]
Nigam S, Sahu A. Estimation of antimicrobial and phytochemical activity of Clitoriaternatea stem and leaf extracts against some selected bacterial strain. Int J Res Dev Pharm L Sci 2014; 3: 1194-9.
[29]
Haqq SM, Prakash P. Antibacterial activity of flower and stem extracts of Chrysanthemum coronarium. Int J Pharma Bio Sci 2015; 6: 411-4.
[30]
Burman S, Bhattacharya K, Mukherjee D, Chandra G. Antibacterial efficacy of leaf extracts of Combretum album Pers. against some pathogenic bacteria. BMC Complement Altern Med 2018; 18(1): 213.
[http://dx.doi.org/10.1186/s12906-018-2271-0] [PMID: 29996826]
[31]
Louis H, Linus MN, Israt A, Innocent J, Amos PI, Magu TO. Antimicrobial Activity of Stem, Leave and Root Plant Extract of Sclerocarya birrea and Sterculia setigera against Some Selected Microorganisms. World Scientific News 2018; 92: 309-26.
[32]
Sato M, Tsuchiya H, Miyazaki T, Ohyama M, Tanaka T, Iinuma M. Antibacterial activity of flavanostilbenes against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol 1995; 21(4): 219-22.
[http://dx.doi.org/10.1111/j.1472-765X.1995.tb01045.x] [PMID: 7576511]
[33]
Silva O, Duarte A, Pimentel M, et al. Antimicrobial activity of Terminalia macroptera root. J Ethnopharmacol 1997; 57(3): 203-7.
[http://dx.doi.org/10.1016/S0378-8741(97)00068-8] [PMID: 9292414]
[34]
Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi T. Antibacterial and antiandrogen flavonoids from Sophora flavescens. J Nat Prod 1999; 62(12): 1595-9.
[http://dx.doi.org/10.1021/np990051d] [PMID: 10654410]
[35]
Fukai T, Oku Y, Hou AJ, Yonekawa M, Terada S. Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus. Chem Biodivers 2004; 1(9): 1385-90.
[http://dx.doi.org/10.1002/cbdv.200490101] [PMID: 17191916]
[36]
Sini S, Malathy NS. Antimicrobial properties of roots of medicinal plants. Anc Sci Life 2005; 25(2): 62-5.
[PMID: 22557193]
[37]
Jeyachandran R, Mahesh A, Cindrella L, Sudhakar S, Pazhanichamy K. Antibacterial activity of plumbagin and root extracts of Plumbago zeylanica L. Acta Biol Cracov Ser; Bot 2009; 51: 17-22.
[38]
Dalal K, Ahlawat S, Munjal H, Patra A. Antibacterial activity of roots of Cicer arietinum Linn. J Chem Pharm Res 2010; 2: 43-6.
[39]
Uddin M, Ghufran MA, Idrees M, Irshad M, Jabeen S, Ahmad W, et al. Antibacterial activity of methanolic root extract of Asparagus racemosus. J Pub Health Biol Sci 2012; 1: 32-5.
[40]
Mehta K, Patel BN, Jain BK. Antimicrobial Activity of root extract of Phyllanthus fraternus Webster: An Ethnomedicinal plant. Res J Recent Sci 2014; 3: 275-8.
[41]
Kumari M, Gupta RP. In vitro antibacterial effect of Withania somnifera root extract on Escherichia coli. Vet World 2015; 8(1): 57-60.
[http://dx.doi.org/10.14202/vetworld.2015.57-60] [PMID: 27046997]
[42]
Ingle KP, Deshmukh AG, Padole DA, Dudhare MS, Moharil MP, Khelurkar VC. Antibacterial activity of Jatropha curcas extract against Pseudomonas fluorescence and Xanthomonas auxinopodis (P.V. citri). J Pharmacogn Phytochem 2017; 6: 2169-73.
[43]
Cercós AP. Antimicrobial activity of the epicarp of the fruits of Paulownia fortunei and Paulownia tomentosa Rev Argent Microbiol 1982; 14(2): 111-4.
[PMID: 6821518]
[44]
Parekh J, Chanda S. In vitro antimicrobial activity of Trapa natans L. fruit rind extracted in different solvents. Afr J Biotechnol 2007; 6: 766-70.
[45]
Aneja KR, Jundishapur RJ. Evaluation of antimicrobial properties of fruit extracts of Terminalia chebula against dental caries pathogens. J Microbiol 2009; 2: 105-11.
[46]
Parekh J, Chanda S. In vitro antibacterial activity of the crude methanol extract of Woodfordia fruticosa Kurz. flower (Lythraceae). Braz J Microbiol 2007; 38: 204-7.
[http://dx.doi.org/10.1590/S1517-83822007000200004]
[47]
Malaviya A, Mishra N. Antimicrobial activity of tropical fruits. Biological Forum –. Int J 2011; 3: 1-4.
[48]
Mukherjee D, Bhattacharya K, Chandra G. Extracts of edible pods of Moringa oleifera lam. (Moringace-ae) as novel antibacterial agent against some pathogenic bacteria Int J Pharm Bio Sci 2015; 6(B): 513-20.
[49]
Mukherjee D, Singha Ray A, Bhattacharya K, Chandra G. Strobilus extractives of Thuja orientalis as novel antibacterial agent against some pathogenic bacteria 2016.
[50]
Mukherjee D, Chandra G. Flower extracts of Quisqualis indica as novel antibacterial agent against some pathogenic bacteria. Ann Pharmacol Pharm 2017; 2(7): 1040.
[51]
Chatterjee SK, Bhattacharjee I, Chandra G. Bactericidal activities of some common herbs in India. Pharm Biol 2007; 45(5): 350-4.
[http://dx.doi.org/10.1080/13880200701212940]
[52]
Bhattacharjee I, Chatterjee SK, Chandra G. Isolation and identification of antibacterial components in seed extracts of Argemone mexicana L. (Papaveraceae). Asian Pac J Trop Med 2010; 3(7): 547-51.
[http://dx.doi.org/10.1016/S1995-7645(10)60132-0]
[53]
World Health Organization (WHO). The promotion and development of traditional medicine 1978.
[54]
Nostro A, Germanò MP, D’angelo V, Marino A, Cannatelli MA. Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Lett Appl Microbiol 2000; 30(5): 379-84.
[http://dx.doi.org/10.1046/j.1472-765x.2000.00731.x] [PMID: 10792667]
[55]
Rawani A, Pal S, Chandra G. Evaluation of antibacterial properties of four plant extracts against human pathogens. Asian Pac J Trop Biomed 2011; 1(1): S71-5.
[http://dx.doi.org/10.1016/S2221-1691(11)60127-5]
[56]
Chatterjee SK, Bhattacharjee I, Chandra G. Isolation and identification of bioactive antibacterial components in leaf extracts of Vangueria spinosa (Rubiaceae). Asian Pac J Trop Med 2011; 4(1): 35-40.
[http://dx.doi.org/10.1016/S1995-7645(11)60028-X] [PMID: 21771412]
[57]
Chatterjee SK, Bhattacharjee I, Chandra G. In vitro synergistic effect of doxycycline & ofloxacin in combination with ethanolic leaf extract of Vangueria spinosa against four pathogenic bacteria. Indian J Med Res 2009; 130(4): 475-8.
[PMID: 19942754]
[58]
Iwu MW, Duncan AR, Okunji CO. New antimicrobials of plant originPerspectives on New Crops and New Uses. Alexandria, VA: ASHS Press 1999; pp. 457-62.